ADRA1B Antibodies

AND ADRA1B ELISA kits, ADRA1B Proteins

Many biological assays use antibodies to detect ADRA1B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ADRA1B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ADRA1B antibodies...

We validate the specificity of these antibodies to ADRA1B by testing them on tissues known to express ADRA1B positively and negatively. Browse below to find the ADRA1B antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ADRA1B Infographic by Boster Bio

All ADRA1B Products

Product

Figures

Specificity

Applications

Price

Anti-AR-Alpha 1B ADRA1B Antibody

Human, Rat

IF, WB

$405
Cat # A04856-1
100ul

Anti-AR-alpha B ADRA1B Antibody

Human, Mouse, Rat

ELISA, IF, WB

$380
Cat # A04856-2
100ul

ADRA1B Overview

Facts about Alpha-1B adrenergic receptor.

ADRA1B 3D structure. Source: alphafold

Alpha-1B adrenergic receptor (ADRA1B)

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins.

Atomic ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes. .

Gene Information

Human
Gene Name:	ADRA1B
Uniprot:	P35368
Entrez:	147

Family

Belongs to:

G-protein coupled receptor 1 family

Alternative Names

a-1B AdrenergicR; ADRA1; ADRA1B; adrenergic, alpha-1B-, receptor; alpha-1B Adrenergic R; alpha-1B adrenergic receptor; alpha1B AdrenergicR; Alpha-1B adrenoceptor; Alpha-1B adrenoreceptor; alpha-1B-adrenergic receptor; ALPHA1BAR

Molecular Weight

Mass (kDA):
56.836 kDA

Genomic Context


Human

Location:	5q33.3
Sequence:	5; NC_000005.10 (159916482..159989205)

Subcellular Localizations

Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasm. Membrane, caveola. Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes.

Diseases

Pathologic Vasoconstriction
Hypertensive Disease
Hypertrophy
Heart Failure
Nervousness
Pertussis
Cardiac Hypertrophy
Nerve Degeneration
Malignant Neoplasms
Cardiomyopathy, Dilated
Cardiomyopathies
Neoplasms
Epilepsy

Stenosis
Neurodegenerative Disorders
Stress, Psychological
Liver Carcinoma
Cholera
Myocardial Ischemia
Cardiovascular Diseases

Interacting Proteins

ACKR3
CXCR4
DRD4

Pathways

Localization
Vasoconstriction
Reverse Transcription
Secretion
Cell Proliferation
Cell Migration
Receptor Internalization
Cellular Localization
Hypersensitivity
Regulation Of Blood Pressure
Cell Death
Glucose Homeostasis
Receptor Recycling

Receptor Transactivation
Innervation
Excretion
Aging
Muscle Contraction
Sensitization
Cell Cycle

PTMs

Phosphorylation
Reduction
Palmitoylation

Nitration
Biotinylation
Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ADRA1B

References

PMID: 1328250 by Ramarao C.S., et al. Genomic organization and expression of the human alpha 1B-adrenergic receptor.

PMID: 8183249 by Forray C., et al. The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype.