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ADAR Antibodies
AND ADAR ELISA kits, ADAR Proteins
Many biological assays use antibodies to detect ADAR, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ADAR in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ADAR antibodies...
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ADAR Infographic by Boster Bio
All ADAR Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, IF, IHC, ICC, WB
$370
Cat # A00869-2
100 μg/vial
Cat # A00869-2
100 μg/vial
ADAR Overview
Facts about Double-stranded RNA-specific adenosine deaminase.
Double-stranded RNA-specific adenosine deaminase (ADAR)
Catalyzes the hydrolytic deamination of adenosine into inosine in double-stranded RNA (dsRNA) called A-to-I RNA editing (PubMed:7972084, PubMed:7565688, PubMed:12618436). This may affect gene expression and function in a variety of ways which have mRNA translation by altering codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by altering sequences involved with nuclease recognition; genetic stability in the event of RNA virus genomes by altering sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions.
Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer- associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3).
Gene Information
| Human | |
|---|---|
| Gene Name: | ADAR |
| Uniprot: | P55265 |
| Entrez: | 103 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
ADAR1DSH; adenosine deaminase, RNA-specific; DRADAP136; DSRADadenosine deaminase acting on RNA 1-A; EC 3.5.4; EC 3.5.4.-; G1P1double-stranded RNA-specific adenosine deaminase; IFI-4; IFI4dsRNA adenosine deaminase; interferon-induced protein 4; Interferon-inducible protein 4; K88DSRBP; p136,136 kDa double-stranded RNA-binding protein
Molecular Weight
Mass (kDA):
136.066 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q21.3 |
| Sequence: | 1; NC_000001.11 (154582057..154627997, complement) |
Tissue Specificity
Ubiquitously expressed, highest levels were found in brain and lung (PubMed:7972084). Isoform 5 is expressed at higher levels in astrocytomas as compared to normal brain tissue and expression increases strikingly with the severity of the tumor, being higher in the most aggressive tumors.
Subcellular Localizations
[Isoform 1]: Cytoplasm. Nucleus. Shuttles between the cytoplasm and nucleus (PubMed:7565688, PubMed:24753571). Nuclear import is mediated by TNPO1 (PubMed:24753571).; [Isoform 5]: Cytoplasm. Nucleus. Nucleus, nucleolus. Predominantly nuclear but can shuttle between nucleus and cytoplasm. TNPO1 can mediate its nuclear import whereas XPO5 can mediate its nuclear export.
Diseases
- Nervousness
- Hepatitis
- Malignant Neoplasms
- Hepatitis D Infection
- Neoplasms
- Nerve Degeneration
- Pigmentation Disorders
- Symmetrical Dyschromatosis Of Extremities
- Epilepsy
- Virus Diseases
- Skin Diseases, Genetic
- Sclerosis
- Amyotrophic Lateral Sclerosis
Interacting Proteins
- DICER1
- TARBP2
- UPF1
Pathways
- Rna Interference
- Translation
- Gene Silencing
- Localization
- Immune Response
- Rna Processing
- Pathogenesis
- Brain Development
- Locomotion
- Regulation Of Gene Expression
- Adenosine To Inosine Editing
- Protein Phosphorylation
- Aging
PTMs
- Deamination
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ADAR
bosterbio.com/bosterbio-gene-info-cards/ADAR
References
PMID: 7972084 by Kim U., et al. Molecular cloning of cDNA for double-stranded RNA adenosine deaminase, a candidate enzyme for nuclear RNA editing.
PMID: 7565688 by Patterson J.B., et al. Expression and regulation by interferon of a double-stranded-RNA- specific adenosine deaminase from human cells: evidence for two forms of the deaminase.