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Alpha-actinin-4 Antibodies
AND ACTN4 ELISA kits, Alpha-actinin-4 Proteins
Many biological assays use antibodies to detect Alpha-actinin-4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Alpha-actinin-4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Alpha-actinin-4 antibodies...
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ACTN4 Infographic by Boster Bio
All ACTN4 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PB9974
100 μg/vial
Cat # PB9974
100 μg/vial
Anti-alpha Actinin 4 ACTN4 Monoclonal Antibody
2 Citations
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M01975
100 μl
Cat # M01975
100 μl
Human
IHC, WB
$431
Cat # M01975-1
100uL
Cat # M01975-1
100uL
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$405
Cat # A01975
100ul
Cat # A01975
100ul
ACTN4 Overview
Facts about Alpha-actinin-4.
Alpha-actinin-4 (ACTN4)
F-actin cross-linking protein that is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable).
Probably involved in vesicular trafficking through its association with the CART complex. The CART complex is necessary for effective transferrin receptor recycling but not for EGFR degradation (PubMed:15772161).
Gene Information
| Human | |
|---|---|
| Gene Name: | ACTN4 |
| Uniprot: | O43707 |
| Entrez: | 81 |
Family
| Belongs to: |
|---|
| alpha-actinin family |
Alternative Names
actinin alpha4 isoform; actinin, alpha 4; ACTININ-4; alpha-actinin-4; DKFZp686K23158; F-actin cross-linking protein; focal segmental glomerulosclerosis 1; FSGS; FSGS1; Non-muscle alpha-actinin 4
Molecular Weight
Mass (kDA):
104.854 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19q13.2 |
| Sequence: | 19; NC_000019.10 (38647649..38731589) |
Tissue Specificity
Widely expressed.
Subcellular Localizations
Nucleus. Cytoplasm. Cell junction. Cytoplasm, cytoskeleton, stress fiber. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Nuclear translocation can be induced by the PI3 kinase inhibitor wortmannin or by cytochalasin D. Exclusively localized in the nucleus in a limited number of cell lines (breast cancer cell line MCF-7, oral floor cancer IMC-2, and bladder cancer KU-7).
Diseases
- Focal Glomerulosclerosis
- Glomerulosclerosis (disorder)
- Segmental Glomerulosclerosis
- Kidney Diseases
- Nephrotic Syndrome
- Proteinuria Of Undiagnosed Cause
- Neoplasms
- Malignant Neoplasms
- Tissue Adhesions
- Neoplasm Metastasis
- Carcinoma
- Kidney Failure, Chronic
- Cell Invasion
Interacting Proteins
- CTNNB1
- IQGAP1
- LCMT2
- MEOX2
- MYOZ2
- RARA
- TJP1
Pathways
- Cell Motility
- Pathogenesis
- Localization
- Glomerular Filtration
- Cell Adhesion
- Excretion
- Transport
- Translation
- Cell Proliferation
- Endocytosis
- Cell Migration
- Cell Growth
- Rna Interference
PTMs
- Phosphorylation
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ACTN4
bosterbio.com/bosterbio-gene-info-cards/ACTN4
References
PMID: 10656685 by Nikolopoulos S.N., et al. The human non-muscle alpha-actinin protein encoded by the ACTN4 gene suppresses tumorigenicity of human neuroblastoma cells.
PMID: 22567897 by Aksenova V.I.U., et al. Novel splicing isoform of actin-binding protein alpha-actinin 4 in epidermoid carcinoma cells A431.
2 Publications of Boster Alpha-actinin-4 Antibodies & ELISA Kits
- PubMed ID: 30745528, Hu H,Xue J,Dong R,Zhao Y,Song C,Zhao H,Hescheler J,Zhang Y,Liang H.STAT3 Phospho...
- PubMed ID: 30745528, STAT3 Phosphorylation Mediating DMSO's Function on Fetal Cardiomyocyte Prolifera...
*More publications can be found for each product on its corresponding product page