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Actin-like protein 6A Antibodies
AND ACTL6A ELISA kits, Actin-like protein 6A Proteins
Many biological assays use antibodies to detect Actin-like protein 6A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Actin-like protein 6A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Actin-like protein 6A antibodies...
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ACTL6A Infographic by Boster Bio
All ACTL6A Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IP, IF, IHC, ICC, WB
$370
Cat # M05553
100 μl
Cat # M05553
100 μl
Human, Mouse, Rat
ELISA
$480
Cat # EKC1667
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1667
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse
IP, IF, IHC, ICC, WB
$405
Cat # A05553-1
100ul
Cat # A05553-1
100ul
ACTL6A Overview
Facts about Actin-like protein 6A.
Actin-like protein 6A (ACTL6A)
Part of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by changing DNA-histone contacts within a nucleosome within an ATP-dependent manner. Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix.
Belongs to the neural progenitors- specific chromatin remodeling complex (npBAF complex) and is necessary for the proliferation of neural progenitors. During neural development a change from a stem/progenitor into a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become dedicated to their adult condition.
Gene Information
| Human | |
|---|---|
| Gene Name: | ACTL6A |
| Uniprot: | O96019 |
| Entrez: | 86 |
Family
| Belongs to: |
|---|
| actin family |
Alternative Names
actin-like 6A; actin-like protein 6A; actin-related protein 4,53 kDa BRG1-associated factor A; Actin-related protein Baf53a; Actl6; Arp4; arpNbeta; BAF complex 53 kDa subunit; Baf53a; BAF53AACTL6; BAF53MGC5382; BRG1-associated factor 53A; hArpN beta; INO80 complex subunit K; INO80KARPN-BETA
Molecular Weight
Mass (kDA):
47.461 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3q26.33 |
| Sequence: | 3; NC_000003.12 (179562880..179588407) |
Subcellular Localizations
Nucleus.
Diseases
- Neoplasms
- Retinoblastoma
- Cell Transformation, Neoplastic
- Congenital Abnormality
- Pediatric Neoplasm
- Rhabdomyosarcoma
- Nerve Degeneration
- Uterine Cervical Neoplasm
- Spina Bifida
- Kidney Neoplasm
- Malignant Tumor Of Cervix
- Nephroblastoma
Interacting Proteins
- YY1
Pathways
- Chromatin Remodeling
- Atp-dependent Chromatin Remodeling
- Cell Proliferation
- Gene Silencing
- Regulation Of Gene Expression
- Localization
- Histone H4 Acetylation
- Viral Transcription
- Spindle Checkpoint
- Cell Death
PTMs
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ACTL6A
bosterbio.com/bosterbio-gene-info-cards/ACTL6A
References
PMID: 9845365 by Zhao K., et al. Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling.
PMID: 10380635 by Harata M., et al. Two isoforms of a human actin-related protein show nuclear localization and mutually selective expression between brain and other tissues.