Actin-like protein 6B Antibodies

AND ACTL6B ELISA kits, Actin-like protein 6B Proteins

Many biological assays use antibodies to detect Actin-like protein 6B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Actin-like protein 6B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Actin-like protein 6B antibodies...

We validate the specificity of these antibodies to Actin-like protein 6B by testing them on tissues known to express ACTL6B positively and negatively. Browse below to find the ACTL6B antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ACTL6B Infographic by Boster Bio

All ACTL6B Products

Product

Figures

Specificity

Applications

Price

Anti-Actin-like protein 6B ACTL6B Antibody

Human, Mouse, Rat

IF, IHC, WB

$405
Cat # A09264
100ul

BAF53b (ACTL6B) (NM_016188) Human Over-expression Lysate

Human

$628
Cat # LS051412
100 µg

ACTL6B Overview

Facts about Actin-like protein 6B.

ACTL6B 3D structure. Source: alphafold

Actin-like protein 6B (ACTL6B)

Part of SWI/SNF chromatin remodeling complexes that carry out crucial enzymatic actions, changing chromatin structure by altering DNA-histone contacts within a nucleosome within an ATP-dependent method. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex), as such plays a role in remodeling mononucleosomes in an ATP-dependent manner, and is needed for postmitotic neural development and dendritic outgrowth.

During neural development a switch from a stem/progenitor into a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult condition. The transition from proliferating neural stem/progenitor cells into postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes.

Gene Information

Human
Gene Name:	ACTL6B
Uniprot:	O94805
Entrez:	51412

Family

Belongs to:

actin family

Alternative Names

53 kDa BRG1-associated factor B; actin-like 6; actin-like 6B; Actin-related protein Baf53b; ACTL6; arpNalpha; BAF53Bactin-like protein 6B; BRG1-associated factor 53B; hArpN alpha

Molecular Weight

Mass (kDA):
46.877 kDA

Genomic Context


Human

Location:	7q22.1
Sequence:	7; NC_000007.14 (100643097..100656448, complement)

Subcellular Localizations

Nucleus.

Diseases

Carcinoma
Congenital Abnormality
Embryonal Carcinoma
Nervousness
Spina Bifida

Pathways

Chromatin Remodeling
Brain Development
Localization

Research Areas

Extracellular Matrix

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ACTL6B

References

PMID: 9799793 by Gloeckner G., et al. Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes.

PMID: 10380635 by Harata M., et al. Two isoforms of a human actin-related protein show nuclear localization and mutually selective expression between brain and other tissues.