Aggrecan core protein Antibodies

AND ACAN ELISA kits, Aggrecan core protein Proteins

Many biological assays use antibodies to detect Aggrecan core protein, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Aggrecan core protein in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Aggrecan core protein antibodies...

We validate the specificity of these antibodies to Aggrecan core protein by testing them on tissues known to express ACAN positively and negatively. Browse below to find the ACAN antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ACAN Infographic by Boster Bio

All ACAN Products

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Specificity

Applications

Price

Human Aggrecan/ACAN ELISA Kit PicoKine®

8 Q&As

Human

ELISA

$450
Cat # EK0909
96 wells/kit, with removable strips.

Human Aggrecan/ACAN PicoKine® Quick ELISA Kit

1 Q&As

Human

ELISA

$499
Cat # FEK0909
96 wells/kit, with removable strips.

Anti-Aggrecan core protein ACAN Antibody

Human, Mouse, Rat

$405
Cat # A04655
100ul

Anti-Aggrecan ACAN Antibody

Human, Rat

$405
Cat # A04655-1
100ul

Anti-Aggrecan Rabbit Monoclonal Antibody

Human

IHC

$370
Cat # M04655-1
100 μl/vial

ACAN Overview

Facts about Aggrecan core protein.

ACAN 3D structure. Source: alphafold

Aggrecan core protein (ACAN)

This proteoglycan is a significant component of extracellular matrix of cartilagenous tissues. A significant role of this protein is to resist compression in cartilage.

It binds avidly to hyaluronic acid via an N-terminal globular region. .

Gene Information

Human
Gene Name:	ACAN
Uniprot:	P16112
Entrez:	176

Family

Belongs to:

aggrecan/versican proteoglycan family

Alternative Names

AGC1SEDK; aggrecan core protein; aggrecan; Cartilage-specific proteoglycan core protein; Chondroitin sulfate proteoglycan 1; Chondroitin sulfate proteoglycan core protein 1; CSPCP; CSPG1aggrecan 1; CSPGCP; large aggregating proteoglycan; MSK16AGCAN

Molecular Weight

Mass (kDA):
261.329 kDA

Genomic Context


Human

Location:	15q26.1
Sequence:	15; NC_000015.10 (88803436..88875354)

Tissue Specificity

Restricted to cartilages.

Subcellular Localizations

Secreted, extracellular space, extracellular matrix.

Diseases

Degenerative Polyarthritis
Osteoarthritis, Knee
Hypertrophy
Intervertebral Disc Degeneration
Arthritis
Dwarfism
Abnormal Degeneration
Hypoxia
Dysplasia
Malignant Neoplasms
Osteochondrodysplasias
Variable Number Tandem Repeat

Arthropathy
Anaplasia
Neoplasms
Rheumatoid Arthritis
Osteoarthritis Of Hip
Mixed Salivary Gland Tumor
Intervertebral Disk Displacement

Pathways

Pathogenesis
Ossification
Regeneration
Secretion
Dedifferentiation
Cell Adhesion
Proteolysis
Cell Proliferation
Endochondral Ossification
Localization
Transport
Cell Migration
Developmental Process

Cellular Senescence
Cell Fate Determination
Protein Secretion
Chondrocyte Hypertrophy
Chondrocyte Differentiation
Chondrocyte Proliferation
Cartilage Development

PTMs

Cleavage
Sulphation

Phosphorylation
Deglycosylation

Research Areas

Cancer
Mesenchymal Stem Cell Markers
Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ACAN

References

PMID: 1985970 by Doege K.J., et al. Complete coding sequence and deduced primary structure of the human cartilage large aggregating proteoglycan, aggrecan. Human-specific repeats, and additional alternatively spliced forms.

PMID: 7574678 by Ilic M.Z., et al. Catabolism of aggrecan by explant cultures of human articular cartilage in the presence of retinoic acid.