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- Table of Contents
2 Citations 5 Q&As
Facts about Bile salt export pump.
Human | |
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Gene Name: | ABCB11 |
Uniprot: | O95342 |
Entrez: | 8647 |
Belongs to: |
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ABC transporter superfamily |
ABC member 16, MDR/TAP subfamily; ABC16; ATP-binding cassette sub-family B member 11; ATP-binding cassette, sub-family B (MDR/TAP), member 11; bile salt export pump; BSEP; BSEPPFIC2; EC 3.6.3; EC 3.6.3.44; PFIC-2; PGY4; progressive familial intrahepatic cholestasis 2; sister p-glycoprotein; SPGPBRIC2
Mass (kDA):
146.407 kDA
Human | |
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Location: | 2q31.1 |
Sequence: | 2; NC_000002.12 (168915468..169031396, complement) |
Expressed predominantly, if not exclusively in the liver, where it was further localized to the canalicular microvilli and to subcanalicular vesicles of the hepatocytes by in situ.
Membrane; Multi-pass membrane protein.
In this article, we'll discuss Boster Bio's Anti-ABCB11 Markerand its use in Hepatocellular Cancer and how to improve its performance. We'll also discuss troubleshooting techniques to ensure that your experiments are running smoothly. Ultimately, these guides are valuable assets for your research. Whether you're new to Boster Bio or a veteran researcher, these guides will assist you in optimizing your experiments and achieve desired results.
The Anti-ABCB11 Marker is part of the Picoband(tm) catalog and interacts with Human, Mouse, and Rat. It has 5mg BSA which allows for long-term storage up to -20°C. In addition to its broad spectrum of applications Boster's AntiABCB11 Marker has a great stability profile.
It is now easier to diagnose hepatocellular cancer by using whole-exome capture and high-throughput sequencing. While standard clinicopathological diagnosis of HCC was sought, genetic analysis was performed simultaneously. WES was focused on genes that are related to liver diseases or metabolic disorders. In five days two germline compound heterozygous missense mutations in the ABCB11 gene have been identified. The mutations affected two amino acid positions that are conserved, indicating an adverse effect on cancer growth.
The present study proved that HCC was caused by a biallelic mutagenesis in ABCB11. However, the patient had preserved BSEP expression and had no other fibrosis or inflammation. Using the ABCB11 marker to identify patients with HCC helped speed up the diagnosis process and improved the prognosis. The study also revealed somatic mutations in the NFE2L2 gene, which is the main driver of hepatocellular carcinogenesis in paediatric patients.
ABCC6 is one of the candidate genes for HCC. It is involved in HCC progress and development. An IL2Rgammanull NOD-scid mouse strain used to model HCC in the NSG mouse model is the NSG mouse model. The same amount of cells was placed in the left side of NSG mice. The knockdown of ABCC6 significantly increased the size of tumors and growth curve, as well as tumor weight. These results suggest that ABCC6 may be a factor in promoting HCC growth in the vivo.
ABCB11 ABCB11, an ABC transporter gene, is found in most tissues of eukaryotes. This gene plays an important part in cell signaling as well as drug resistance. Other ABC transporters could be involved in the growth and progression of cancers. However, little is understood about their role in HCC. In one study, ABCC6 was found to be reduced in HCC tissues and associated with improved outcomes for patients suffering from HCC.
In addition to ABCB11, other genes encoding the bile salt export pump ABCC9 and ABCC12/13, were also upregulated. However, ABCC7 and ABCC11 mRNA expression was not associated with the LIHC level of tumor. However the ABCB11 gene was associated to a number of acquired cholestasis. A higher concentration of the protein indicates an increased severity of the disease.
The ABCB11 gene encodes a protein within the human body called the Bile Salt Export Pump. This protein is part of the ABCB11 superfamily and is expressed mostly in the liver. Mutations in the ABCB11 gene increase the risk of developing hepatocellular carcinoma and progressive familial intrahepaticcholestasis. Boster Bio optimizes the ABCB11 marker to facilitate research on diseases-related proteins.
When troubleshooting an electrical system it is essential to take into consideration the possibility that the circuit could be failing due to more than one defect. While serial substitution may work, it can also fail if one of the components is defective. The troubleshooter must identify the component that is at fault in order to fix this issue. One method of increasing the temperature in certain areas of a circuit board is to employ a heat gun or compressed gas.
It is crucial to test each part of a system before you utilize it. This will ensure that the system meets all your needs and avoid any interruptions. Sometimes, the fix involves multiple devices and servers. It is best to know what these systems can and can't do prior to performing troubleshooting. However, if the problem is affecting just one component the troubleshooting process can be more difficult.
In the course of troubleshooting, it is essential to be able to reproduce the problem in order to resolve the issue. This means reducing a system to its most basic form and understanding its behavior. Once the root of the issue has been identified, the troubleshooter is able to substitute well-known components to fix the problem. This process is called serial substitution and is not always exact. A defective component can cause an element to stop working.
Troubleshooting can enhance the overall maintenance operation. Users can troubleshoot their own issues by using detailed record of their asset history which frees the troubleshooting team. In addition, troubleshooting may help reduce the costs of reactive maintenance, which can be extremely high in the absence of the right information. The immediate costs are evident however, the hidden costs, such as repairs that are not planned, can be a problem for the finance department.
PMID: 9806540 by Strautnieks S.S., et al. A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis.
PMID: 16332456 by Hayashi H., et al. Transport by vesicles of glycine- and taurine-conjugated bile salts and taurolithocholate 3-sulfate: a comparison of human BSEP with rat Bsep.
*More publications can be found for each product on its corresponding product page