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- Table of Contents
Facts about Ragulator complex protein LAMTOR3.
Activated Ragulator and Rag GTPases function as a scaffold recruitment mTORC1 to lysosomes where it is in turn triggered. Adapter protein that enhances the efficacy of the MAP kinase cascade facilitating the activation of MAPK2.
Human | |
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Gene Name: | LAMTOR3 |
Uniprot: | Q9UHA4 |
Entrez: | 8649 |
Belongs to: |
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LAMTOR3 family |
LAMTOR3; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3; late endosomal/lysosomal adaptor, MAPK and MTOR activator 3; MAP2K1IP1; Mapbp; MAPK scaffold protein 1; MAPKSP1; MEK binding partner 1; MEK partner 1; MEK-binding partner 1; mitogen-activated protein kinase kinase 1 interacting protein 1; Mitogen-activated protein kinase kinase 1-interacting protein 1; Mitogen-activated protein kinase scaffold protein 1; MP1; PRO0633; Ragulator3
Mass (kDA):
13.623 kDA
Human | |
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Location: | 4q23 |
Sequence: | 4; NC_000004.12 (99878336..99894546, complement) |
Late endosome membrane; Peripheral membrane protein; Cytoplasmic side.
PMID: 20381137 by Sancak Y., et al. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.
PMID: 22980980 by Bar-Peled L., et al. Ragulator is a GEF for the Rag GTPases that signal amino acid levels to mTORC1.