Protein AATF Antibodies

May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket area of RB1 may displace HDAC1 from RB1/E2F complexes, resulting in activation of E2F target genes and cell cycle progression.

Conversely, displacement of HDAC1 from SP1 jumped to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), even though the molecular basis for this phenomenon hasn't been described to date.