Regulator of G-protein signaling 17 (RGS17)

Regulates G protein-coupled receptor signaling cascades, including signaling through muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:15096504).

Binds selectively to GNAZ and GNAI2 subunits, accelerates their GTPase activity and modulates their signaling activities. Negatively regulates mu-opioid receptor-mediated activation of this G-proteins (By similarity).