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- Table of Contents
Facts about Lactosylceramide 4-alpha-galactosyltransferase.
Necessary for the synthesis of the receptor for bacterial verotoxins. .
Human | |
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Gene Name: | A4GALT |
Uniprot: | Q9NPC4 |
Entrez: | 53947 |
Belongs to: |
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glycosyltransferase 32 family |
A14GALTalpha 1,4-galactosyltransferase (globotriaosylceramide synthase, P blood group); A4GALT1; alpha 1,4-galactosyltransferase; Alpha-1,4-galactosyltransferase; alpha-1,4-N-acetylglucosaminyltransferase; alpha4Gal-T1; CD77 synthase; EC 2.4.1.228; Gb3 synthase; Gb3S; Globotriaosylceramide synthase; lactosylceramide 4-alpha-galactosyltransferase; P blood group (P one antigen); P(k) antigen synthase; P(k); P1; P1/Pk synthase; PK; UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase
Mass (kDA):
40.499 kDA
Human | |
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Location: | 22q13.2 |
Sequence: | 22; NC_000022.11 (42692112..42721301, complement) |
Ubiquitous. Highly expressed in kidney, heart, spleen, liver, testis and placenta.
Golgi apparatus membrane; Single-pass type II membrane protein.
PMID: 10748143 by Kojima Y., et al. Molecular cloning of globotriaosylceramide/CD77 synthase, a glycosyltransferase that initiates the synthesis of globo series glycosphingolipids.
PMID: 10747952 by Steffensen R., et al. Cloning and expression of the histo-blood group Pk UDP- galactose:Galbeta1-4Glcbeta1-Cer alpha1,4-galactosyltransferase. Molecular genetic basis of the p phenotype.