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- Table of Contents
70 Citations 13 Q&As
107 Citations 19 Q&As
76 Citations 19 Q&As
37 Citations 1 Q&As
1 Citations 8 Q&As
12 Citations
9 Citations 2 Q&As
5 Citations
1 Citations
Facts about Brain-derived neurotrophic factor.
Major regulator of synaptic transmission and plasticity at adult synapses in several regions of the CNS. The flexibility of BDNF is emphasized by its contribution to a range of adaptive neuronal reactions including long-term potentiation (LTP), long-term depression (LTD), certain kinds of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
Human | |
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Gene Name: | BDNF |
Uniprot: | P23560 |
Entrez: | 627 |
Belongs to: |
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NGF-beta family |
Abrineurin; ANON2; BDNF; brain-derived neurotrophic factor; BULN2; MGC34632; Neurotrophin
Mass (kDA):
27.818 kDA
Human | |
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Location: | 11p14.1 |
Sequence: | 11; NC_000011.10 (27654893..27722030, complement) |
Brain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also expressed in heart, lung, skeletal muscle, testis, prostate and placenta.
Secreted.; [BDNF precursor form]: Secreted. A proportion of BDNF is secreted as immature precursor (proBDNF).
PMID: 2236018 by Jones K.R., et al. Molecular cloning of a human gene that is a member of the nerve growth factor family.
PMID: 1889806 by Maisonpierre P.C., et al. Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations.
*Showing only the more recent 20. More publications can be found for each product on its corresponding product page