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- Table of Contents
1 Citations
2 Citations 10 Q&As
1 Citations 1 Q&As
Facts about Apolipoprotein A-I.
.
Human | |
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Gene Name: | APOA1 |
Uniprot: | P02647 |
Entrez: | 335 |
Belongs to: |
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apolipoprotein A1/A4/E family |
Alp-1; APOA1; Apo-AI; apoA-I; Apolipoprotein A1; Apolipoprotein AI; Apolipoprotein A-I; Brp-14; Ltw-1; Lvtw-1; MGC117399; Sep-1; Sep-2
Mass (kDA):
30.778 kDA
Human | |
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Location: | 11q23.3 |
Sequence: | 11; NC_000011.10 (116835751..116837950, complement) |
Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. The oxidized form at Met-110 and Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype and exposure to cigarette smoking. It is also present in increased levels in aortic lesions relative to native ApoA-I and increased levels are seen with increasing severity of disease.
Secreted.
PMID: 6406984 by Shoulders C.C., et al. Gene structure of human apolipoprotein A1.
PMID: 6304641 by Cheung P., et al. Nucleotide sequence of cloned cDNA of human apolipoprotein A-I.
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