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Product Info Summary
| SKU: | A03886 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-ZIP1 SLC39A1 Antibody
SKU/Catalog Number
A03886
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-ZIP1 SLC39A1 Antibody (Catalog # A03886). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.
Storage & Handling
ZIP1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-ZIP1 SLC39A1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03886)
Host
Rabbit
Contents
ZIP1 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
ZIP1 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human ZIP1. The immunogen is located within amino acids 40 - 90 of ZIP1.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least two isoforms of ZIP1 are known to exist; this antibody will detect both isoforms. ZIP1 antibody is predicted not to cross-react with other ZIP family proteins.
Reactive Species
A03886 is reactive to SLC39A1 in Human, Mouse
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
34250 MW
Background of SLC39A1
ZIP1, also known as ZIRTL (zinc-iron regulated transporter-like), is the first mammalian member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP1 expression is markedly downregulated in a number of cancerous tissues and is thought to function as a tumor suppressor gene in prostate cancer. More recent studies have shown that overexpression of ZIP1 and concomitant increased levels of intracellular zinc in PC-3 cells cause a significant inhibition of NF-κB, leading to down-regulation of the antiapoptotic protein Bcl-2, Bcl-XL, and the apoptosis inhibitor XIAP, reducing the malignant potential of prostate cancer cells in vitro and in vivo.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A03886 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
ZIP1 antibody can be used for detection of ZIP1 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of ZIP1 in mouse kidney tissue lysate with ZIP1 antibody at (A) 1 and (B) 2 μg/mL.
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Immunohistochemistry of ZIP1 in human kidney tissue with ZIP1 antibody at 2.5 μg/mL.
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Immunofluorescence of ZIP1 in human kidney tissue with ZIP1 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For SLC39A1 (Source: Uniprot.org, NCBI)
Gene Name
SLC39A1
Full Name
Zinc transporter ZIP1
Weight
34250 MW
Superfamily
ZIP transporter (TC 2.A.5) family
Alternative Names
ZIP1, ZIRTL, IRT1, ZIP1, CGI-08, CGI-71, Zinc transporter ZIP1, Solute carrier family 39 member 1, ZIP-1 SLC39A1 ZIP1, ZIRTL solute carrier family 39 member 1 zinc transporter ZIP1|solute carrier family 39 (zinc transporter), member 1|solute carrier family 39 (zinc transporter), member 3|zrt- and Irt-like protein 1
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on SLC39A1, check out the SLC39A1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for SLC39A1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-ZIP1 SLC39A1 Antibody (A03886)
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