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Product Info Summary
| SKU: | A14319 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, WB |
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Product info
Product Name
Anti-ZF21 ZFYVE21 Antibody
SKU/Catalog Number
A14319
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-ZF21 ZFYVE21 Antibody (Catalog # A14319). Tested in ELISA, WB, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
ZF21 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-ZF21 ZFYVE21 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A14319)
Host
Rabbit
Contents
ZF21 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
ZF21 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human ZF21. The immunogen is located within the first 50 amino acids of ZF21.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least two isoforms of ZF21 are known to exist; this antibody will detect both isoforms.
Reactive Species
A14319 is reactive to ZFYVE21 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
26506 MW
Background of Zfyve21
ZF21 was initially identified as protein that could bind to the cytoplasmic tail of MT1-MMP (Membrane-type 1 matrix metalloproteinase), a potent invasion-promoting protease. ZF21 is a member of a protein family characterized by the presence of a phosphatidylinositol 3-phosphate-binding FYVE domain and regulates focal adhesions (FAs) and cell movement. Knockdown of ZF21 expression resulted in a delay of FA disassembly following induction of synchronous disassembly of FAs by nocodazole treatment, suggesting that ZF21 is involved in FA disassembly. ZF21 contains a noncanonical pleckstrin homology domain that is a possible therapeutic target to treat metastatic cancer.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A14319 is guaranteed for ELISA, IF, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
ZF21 antibody can be used for detection of ZF21 by Western blot at 1 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of ZF21 in 3T3 cell tissue lysate with ZF21 antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.
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Immunofluorescence of ZF21 in human kidney tissue with ZF21 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For ZFYVE21 (Source: Uniprot.org, NCBI)
Gene Name
ZFYVE21
Full Name
Zinc finger FYVE domain-containing protein 21
Weight
26506 MW
Alternative Names
ZF21, Zinc finger FYVE domain-containing protein 21, ZF21
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on ZFYVE21, check out the ZFYVE21 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for ZFYVE21: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-ZF21 ZFYVE21 Antibody (A14319)
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