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Product Info Summary
| SKU: | A08575 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | ELISA, IHC-P, WB |
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Product info
Product Name
Anti-XEDAR EDA2R Antibody
View all EDA2R/TNFRSF27/XEDAR Antibodies
SKU/Catalog Number
A08575
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-XEDAR EDA2R Antibody (Catalog # A08575). Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human.
Storage & Handling
XEDAR antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-XEDAR EDA2R Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A08575)
Host
Rabbit
Contents
XEDAR Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
XEDAR antibody was raised against recombinant human XEDAR.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
NDST2 antibody is human, mouse and rat reactive. At least two isoforms of NDST2 are known to exist; this antibody will only detect the larger isoform. NDST2 antibody is predicted not to cross-react with other members of the NDST protein family.
Reactive Species
A08575 is reactive to EDA2R in Human
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
32759 MW
Background of EDA2R/TNFRSF27/XEDAR
X-linked ectodysplasin-A2 receptor (XEDAR) is a recently isolated member of the tumor necrosis factor receptor family that is highly expressed during embryonic development and binds to ectodysplatin-A2 (EDA-A2). Two predominantly expressed isoforms, XEDAR-s and XEDAR-L, differ by only a 21-amino region at the juxtamembrane region of the cytoplasmic domain. Neither isoform possesses a death domain and both have been shown to act mainly through TRAF3 and TRAF6 to activate the NF-κB and JNK pathways. Cells transfected with XEDAR and treated with EDA-A2 cause the assembly of a secondary complex containing FADD, caspase-8 and caspase-10, leading to the activation caspase-8 and caspase-3, and finally apoptosis. The EDA-A2-induced apoptosis is dependent on caspase-9 activation, as various pharmacological and genetic inhibitors of caspase-8 blocked apoptosis following EDA-A2 treatment.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A08575 is guaranteed for ELISA, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
XEDAR antibody can be used for the detection of XEDAR by Western blot at 0.5 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 10 μg/mL.
Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of XEDAR in 293 cell lysate with XEDAR antibody at (A) 0.5
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Immunohistochemistry of XEDAR in human skin tissue with XEDAR antibody at 10 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For EDA2R (Source: Uniprot.org, NCBI)
Gene Name
EDA2R
Full Name
Tumor necrosis factor receptor superfamily member 27
Weight
32759 MW
Alternative Names
XEDAR, EDAA2R, EDA-A2R, TNFRSF27, XEDAR, UNQ2448/PRO5727/PRO34080, Tumor necrosis factor receptor superfamily member 27, X-linked ectodysplasin-A2 receptor, EDA-A2 receptor EDA2R EDA-A2R, EDAA2R, TNFRSF27, XEDAR ectodysplasin A2 receptor tumor necrosis factor receptor superfamily member 27|EDA-A2 receptor|X-linked ectodysplasin-A2 receptor|tumor necrosis factor receptor superfamily member XEDAR
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on EDA2R, check out the EDA2R Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for EDA2R: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-XEDAR EDA2R Antibody (A08575)
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