Product Info Summary
SKU: | A09337 |
---|---|
Size: | 100ul |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | WB |
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Product info
Product Name
Anti-Xaa-Pro aminopeptidase 2 XPNPEP2 Antibody
View all Aminopeptidase P2/XPNPEP2 Antibodies
SKU/Catalog Number
A09337
Size
100ul
Form
Liquid
Description
Boster Bio Anti-Xaa-Pro aminopeptidase 2 XPNPEP2 Antibody catalog # A09337. Tested in WB applications. This antibody reacts with Human,Mouse,Rat.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Xaa-Pro aminopeptidase 2 XPNPEP2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A09337)
Host
Rabbit
Contents
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human AAA1 protein.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A09337 is reactive to XPNPEP2 in Human, Mouse, Rat
Applications
A09337 is guaranteed for WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
75625 MW
Background of Aminopeptidase P2/XPNPEP2
Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs. Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1. In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase. Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA. Not involved in replication-dependent histone mRNA degradation.
Ota T., Nat. Genet. 36:40-45(2004).
The MGC Project Team, Genome Res. 14:2121-2127(2004).
Trippe R.,RNA 12:1494-1504(2006).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:1000-1:2000
Validation Images & Assay Conditions
Click image to see more details
Figure 1. Western blotting validation for Anti-Xaa-Pro aminopeptidase 2 XPNPEP2 Antibody A09337
Western blot analysis of extract of various cellsProtein Target Info & Infographic
Gene/Protein Information For XPNPEP2 (Source: Uniprot.org, NCBI)
Gene Name
XPNPEP2
Full Name
Xaa-Pro aminopeptidase 2
Weight
75625 MW
Superfamily
peptidase M24B family
Alternative Names
Aminoacylproline aminopeptidase; Aminopeptidase P2; APP2; EC 3.4.11.9; mAmP; Membrane-bound aminopeptidase P; Membrane-bound AmP; Membrane-bound APP; xaa-Pro aminopeptidase 2; XPNPEP2; X-Pro aminopeptidase 2; X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound XPNPEP2 AEACEI, APP2 X-prolyl aminopeptidase 2 xaa-Pro aminopeptidase 2|X-Pro aminopeptidase 2|X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound|aminoacylproline aminopeptidase|mAmP|membrane-bound APP|membrane-bound AmP|membrane-bound aminopeptidase P
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on XPNPEP2, check out the XPNPEP2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for XPNPEP2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Xaa-Pro aminopeptidase 2 XPNPEP2 Antibody (A09337)
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