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Product Info Summary
| SKU: | A01059 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-VKORC1 Antibody
SKU/Catalog Number
A01059
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-VKORC1 Antibody (Catalog # A01059). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.
Storage & Handling
VKORC1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-VKORC1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01059)
Host
Rabbit
Contents
VKORC1 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
VKORC1 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human VKORC1. The immunogen is located within the first 50 amino acids of VKORC1.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
TFPI antibody is human, mouse and rat reactive. At least two isoforms of TFPI are known to exist; this antibody will detect both isoforms.
Reactive Species
A01059 is reactive to Vkorc1 in Human, Mouse
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
18235 MW
Background of Vkorc1
Vitamin K epoxide reductase complex subunit 1 (VKORC1) is the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form which is essential for blood clotting. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is VKORC1 that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A01059 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
VKORC1 antibody can be used for detection of VKORC1 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 5 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Positive Control
Validation Images & Assay Conditions
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Western blot analysis of VKORC1 in A549 cell lysate with VKORC1 antibody at 1 μg/mL.
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Immunohistochemistry of VKORC1 in human lung tissue with VKORC1 antibody at 2.5 μg/mL.
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Immunofluorescence of VKORC1 in human lung tissue with VKORC1 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For Vkorc1 (Source: Uniprot.org, NCBI)
Gene Name
Vkorc1
Full Name
Vitamin K epoxide reductase complex subunit 1
Weight
18235 MW
Superfamily
VKOR family
Alternative Names
EC 1.1.4.1; EDTP308; FLJ00289; IMAGE3455200; MST576; phylloquinone epoxide reductase; vitamin K dependent clMST134; vitamin K epoxide reductase complex subunit 1; vitamin K epoxide reductase complex, subunit 1; Vitamin K1 2,3-epoxide reductase subunit 1; vitamin K1 epoxide reductase (warfarin-sensitive); VKCFD2; VKORMGC2694 Vkorc1|D7Wsu86, D7Wsu86e|vitamin K epoxide reductase complex, subunit 1|vitamin K epoxide reductase complex subunit 1|phylloquinone epoxide reductase|vitamin K 2,3-epoxide reductase complex subunit 1|vitamin K epoxide reductase subunit I|vitamin K1 2,3-epoxide reductase subunit 1|vitamin K1 epoxide reductase (warfarin-sensitive)
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on Vkorc1, check out the Vkorc1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for Vkorc1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-VKORC1 Antibody (A01059)
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