Anti-VEGI (Vascular Endothelial Growth Inhibitor) TNFSF15 Monoclonal Antibody

Product Name

Anti-VEGI (Vascular Endothelial Growth Inhibitor) TNFSF15 Monoclonal Antibody

View all TL1A/TNFSF15 Antibodies

SKU/Catalog Number

M02402-1

Size

100ug/vial

Form

Liquid

Description

Boster Bio Anti-VEGI (Vascular Endothelial Growth Inhibitor) TNFSF15 Monoclonal Antibody (Catalog # M02402-1). Tested in IHC applications. This antibody reacts with Human.

Storage & Handling

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Cite This Product

Anti-VEGI (Vascular Endothelial Growth Inhibitor) TNFSF15 Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M02402-1)

Host

Mouse

Contents

Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Clonality

Monoclonal

Clone Number

Clone: VEGI/1283

Isotype

IgG1, kappa

Immunogen

Recombinant human VEGI fragment

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

Detects ~52kDa. Heavy chain migrates close to FKBP52 on SDS PAGE.

Reactive Species

M02402-1 is reactive to TNFSF15 in Human

Applications

M02402-1 is guaranteed for IHC Boster Guarantee

Observed Molecular Weight

42 kDa

Calculated molecular weight

27723 MW

Background of TL1A/TNFSF15

VEGI is an anti-angiogenic cytokine that belongs to tumor necrosis factor superfamily, member 15 (TNFSF15). This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Reduced expression of VEGI has been reported as a marker of poor prognosis in breast cancer.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Validation Images & Assay Conditions

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Formalin-fixed, paraffin-embedded human colon carcinoma stained with Anti-VEGI Monoclonal Antibody (VEGI /1283).

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Formalin-fixed, paraffin-embedded human Parathyroid Mass stained with Anti-TNFS15 / VEGI Monoclonal Antibody (VEGI /1283).

Gene/Protein Information For TNFSF15 (Source: Uniprot.org, NCBI)

Alternative Names

MGC129934; MGC129935; TL1A; TL1Vascular endothelial cell growth inhibitor; TNF superfamily ligand TL1A; TNFSF15; tumor necrosis factor (ligand) superfamily, member 15; tumor necrosis factor ligand superfamily member 15; vascular endothelial growth inhibitor-192A; VEGI; VEGI192A; VEGITNF ligand-related molecule 1 TNFSF15 TL1, TL1A, TNLG1B, VEGI, VEGI192A TNF superfamily member 15 tumor necrosis factor ligand superfamily member 15|TNF ligand-related molecule 1|TNF superfamily ligand TL1A|tumor necrosis factor (ligand) superfamily, member 15|tumor necrosis factor ligand 1B|tumor necrosis factor superfamily member 15|vascular endothelial cell growth inhibitor|vascular endothelial growth inhibitor-192A

For more info on TNFSF15, check out the TNFSF15 Infographic

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In this infographic, you will see the following information for TNFSF15: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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