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Product Info Summary
| SKU: | A05870-2 |
|---|---|
| Size: | 100ul |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | IHC, WB |
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Product info
Product Name
Anti-USP19 Antibody
SKU/Catalog Number
A05870-2
Size
100ul
Form
Liquid
Description
Boster Bio Anti-USP19 Antibody catalog # A05870-2. Tested in WB,IHC applications. This antibody reacts with Human,Mouse,Rat.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-USP19 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A05870-2)
Host
Rabbit
Contents
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from internal of human USP19.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A05870-2 is reactive to USP19 in Human, Mouse, Rat
Applications
A05870-2 is guaranteed for IHC, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
145651 MW
Background of USP19
Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked Ubiquitin chains.
Nagase T., DNA Res. 5:355-364(1998).
The MGC Project Team, Genome Res. 14:2121-2127(2004).
Beausoleil S.A., Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:500-1:1000
IHC: 1:50-1:200
Validation Images & Assay Conditions
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Figure 2. Immunohistochemistry validation of USP19 using Anti-USP19 Antibody (A05870-2).
Immunohistochemistry (IHC) analyzes of USP19 pAb in paraffin-embedded human breast carcinoma tissue at 1:50.showing endoplasmic reticulum membrane staining. Negative control (the right)Using PBS instead of primary antibody
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Figure 1. Western blotting validation for Anti-USP19 Antibody A05870-2
Western blot (WB) analysis of USP19 polyclonal antibody at 1:500 dilutionLane1:MCF-7 cell lysate
Lane2:HEK293T cell lysate
Lane3:H9C2 cell lysate
Electrophoresis was performed on a SDS-PAGE gel. To determine SDS-PAGE gel concentration
Protein Target Info & Infographic
Gene/Protein Information For USP19 (Source: Uniprot.org, NCBI)
Gene Name
USP19
Full Name
Ubiquitin carboxyl-terminal hydrolase 19
Weight
145651 MW
Superfamily
peptidase C19 family
Alternative Names
Deubiquitinating enzyme 19; EC 3.1.2.15; EC 3.4.19.12; KIAA0891; Ubiquitin Carboxyl-Terminal Hydrolase 19; ubiquitin specific peptidase 19; ubiquitin thioesterase 19; Ubiquitin Thiolesterase 19; Ubiquitin-specific-processing protease 19; USP19; Zinc finger MYND domain-containing protein 9; ZMYND9; ZMYND9ubiquitin specific protease 19 USP19 ZMYND9 ubiquitin specific peptidase 19 ubiquitin carboxyl-terminal hydrolase 19|deubiquitinating enzyme 19|ubiquitin specific protease 19|ubiquitin thioesterase 19|ubiquitin thiolesterase 19|ubiquitin-specific-processing protease 19|zinc finger MYND domain-containing protein 9
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on USP19, check out the USP19 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for USP19: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-USP19 Antibody (A05870-2)
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