Product Info Summary
SKU: | A08781-1 |
---|---|
Size: | 100ul |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | Flow Cytometry, IP, IF, IHC, ICC, WB |
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Product info
Product Name
Anti-UQCRFS1 Antibody
SKU/Catalog Number
A08781-1
Size
100ul
Form
Liquid
Description
Boster Bio Anti-UQCRFS1 Antibody catalog # A08781-1. Tested in WB,ICC,IF,IHC,Flow Cytometry,IP applications. This antibody reacts with Human,Mouse,Rat.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-UQCRFS1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A08781-1)
Host
Rabbit
Contents
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human NEDL2
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A08781-1 is reactive to UQCRFS1 in Human, Mouse, Rat
Applications
A08781-1 is guaranteed for Flow Cytometry, IP, IF, IHC, ICC, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
29668 MW
Background of UQCRFS1
A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner By similarity. Plays also a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA.
Ota T., Nat. Genet. 36:40-45(2004).
Ebert L., Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Boulon S., Mol. Cell 16:777-787(2004).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:500-1:2,000
ICC: 1:500-1:2,000
IHC: 1:50-1:200
FC: 1:50-1:100
FC: 1:10-1:50
Validation Images & Assay Conditions
![a08781 1 anti uqcrfs1 antibody icc testing 2 a08781 1 anti uqcrfs1 antibody icc testing 2](https://www.bosterbio.com/media/catalog/product/a/0/a08781-1-anti-uqcrfs1-antibody-icc-testing-2.jpg)
Click image to see more details
Figure 2. Immunocytochemistry staining of UQCRFS1 using Anti-UQCRFS1 Antibody (A08781-1).
ICC staining UQCRFS1 in 293T cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde![a08781 1 anti uqcrfs1 antibody wb testing 1 a08781 1 anti uqcrfs1 antibody wb testing 1](https://www.bosterbio.com/media/catalog/product/a/0/a08781-1-anti-uqcrfs1-antibody-wb-testing-1.jpg)
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Figure 1. Western blotting validation for Anti-UQCRFS1 Antibody A08781-1
Western blot analysis of UQCRFS1 on different lysates using anti-UQCRFS1 antibody at 1/1Protein Target Info & Infographic
Gene/Protein Information For UQCRFS1 (Source: Uniprot.org, NCBI)
Gene Name
UQCRFS1
Full Name
Cytochrome b-c1 complex subunit Rieske, mitochondrial
Weight
29668 MW
Superfamily
Rieske iron-sulfur protein family
Alternative Names
Complex III subunit 5; Cytochrome b-c1 complex subunit 5; cytochrome b-c1 complex subunit Rieske, mitochondrial; EC 1.10.2.2; Rieske iron-sulfur protein; RIP1; RIS1; RISPUbiquinol-cytochrome c reductase iron-sulfur subunit; ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1; UQCR5 UQCRFS1 MC3DN10, RIP1, RIS1, RISP, UQCR5 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 cytochrome b-c1 complex subunit Rieske, mitochondrial|Rieske iron-sulfur protein|Rieske protein UQCRFS1|complex III subunit 5|cytochrome b-c1 complex subunit 5|epididymis secretory sperm binding protein|ubiquinol-cytochrome c reductase iron-sulfur subunit
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on UQCRFS1, check out the UQCRFS1 Infographic
![UQCRFS1 infographic](/media/images/gene-infographic-example.jpg)
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for UQCRFS1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-UQCRFS1 Antibody (A08781-1)
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