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Product Info Summary
| SKU: | A03864 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-Unc93b UNC93B1 Antibody
SKU/Catalog Number
A03864
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Unc93b UNC93B1 Antibody (Catalog # A03864). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Unc93b antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Unc93b UNC93B1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03864)
Host
Rabbit
Contents
Unc93b Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Unc93b antibody was raised against a 19 amino acid synthetic peptide from near the amino terminus of human Unc93b. The immunogen is located within amino acids 80 - 130 of Unc93b.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Multiple isoforms of Unc93b are known to exist. This antibody will not cross-react with Unc93a.
Reactive Species
A03864 is reactive to UNC93B1 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
66631 MW
Background of UNC93B
The endoplasmic reticulum (ER) protein Unc93b, a human homolog of the C. elegans Unc93 gene, was initially identified by a forward genetic screen using N-ethyl-N-nitrosourea where a histidine-to-arginine substitution in Unc93b caused defects in Toll-like receptor (TLR) 3, 7 and 9 signaling. Unlike Unc93a, another homolog of the C. elegans Unc93 gene whose function is unknown, Unc93b specifically interacts with TLR3, 7 and 9; the histidine-to-arginine point mutation used to identify Unc93b abolishes this interaction. Mice carrying this point mutation are highly susceptible to infection with a number of viruses, indicating that Unc93b plays an important role in innate immunity.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A03864 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Unc93b antibody can be used for the detection of Unc93b by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of Unc93b in human heart tissue lysate with Unc93b antibody at (A) 0.5 and (B) 1 μg/mL.
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Immunofluorescence of Unc93b in Human Heart cells with Unc93b antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For UNC93B1 (Source: Uniprot.org, NCBI)
Gene Name
UNC93B1
Full Name
Protein unc-93 homolog B1
Weight
66631 MW
Superfamily
unc-93 family
Alternative Names
IIAE1, UNC93, UNC93B, Unc-93B1, Protein unc-93 homolog B1 Unc93b1|Unc-93B1, Unc93b|unc-93 homolog B1, TLR signaling regulator|protein unc-93 homolog B1|unc-93 homolog B
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on UNC93B1, check out the UNC93B1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for UNC93B1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Unc93b UNC93B1 Antibody (A03864)
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