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Product Info Summary
| SKU: | A02298-2 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-TNFRSF14 Antibody
View all HVEM/TNFRSF14 Antibodies
SKU/Catalog Number
A02298-2
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-TNFRSF14 Antibody (Catalog # A02298-2). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.
Storage & Handling
TNFRSF14 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-TNFRSF14 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02298-2)
Host
Rabbit
Contents
TNFRSF14 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
TNFRSF14 antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human TNFRSF14. The immunogen is located within amino acids 20 - 70 of TNFRSF14.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Multiple isoforms of TNFRSF14 are known to exist.
Reactive Species
A02298-2 is reactive to TNFRSF14 in Human, Mouse
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
30392 MW
Background of HVEM/TNFRSF14
Tumor necrosis factor receptor (TNFR) superfamily members are defined by cysteine-rich domains in their extracellular regions that bind TNF-related ligands that share a common structural homology in their extracellular domain. TNFRSF14 was initially identified as the Herpesvirus entry mediator and upon binding to the herpes simplex virus (HSV) envelope glycoprotein D or either of its natural ligands LIGHT and lymphotoxin alpha (LT), activates the transcription factors NF-κB and AP-1. Activation of this signal transduction pathway in T cells stimulates T cell proliferation and cytokine production, leading to inflammation and enhanced CTL-mediated tumor immunity, suggesting that these proteins may be useful as potential targets for controlling cellular immune responses.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A02298-2 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
TNFRSF14 antibody can be used for the detection of TNFRSF14 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 1 μg/mL. For immunofluorescence start at 10 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of TNFRSF14 in mouse thymus tissue lysate with TNFRSF14 antibody at (A) 1 and (B) 2 μg/mL.
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Immunohistochemistry of TNFRSF14 in mouse thymus tissue with TNFRSF14 antibody at 1 μg/mL.
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Immunofluorescence of TNFRSF14 in Mouse Thymus tissue with TNFRSF14 antibody at 10 μg/mL.
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Western blot analysis of 125 ng of TNFRSF14 with TNFRSF14 antibody at 1 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For TNFRSF14 (Source: Uniprot.org, NCBI)
Gene Name
TNFRSF14
Full Name
Tumor necrosis factor receptor superfamily member 14
Weight
30392 MW
Superfamily
tumor necrosis factor receptor superfamily
Alternative Names
TR2, ATAR, HVEA, HVEM, CD270, LIGHTR, UNQ329/PRO509, Tumor necrosis factor receptor superfamily member 14, Herpes virus entry mediator A, Herpesvirus entry mediator A TNFRSF14 ATAR, CD270, HVEA, HVEM, LIGHTR, TR2 TNF receptor superfamily member 14 tumor necrosis factor receptor superfamily member 14|CD40-like protein|herpes virus entry mediator A|tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)|tumor necrosis factor receptor-like gene2
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TNFRSF14, check out the TNFRSF14 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TNFRSF14: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-TNFRSF14 Antibody (A02298-2)
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