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Product Info Summary
| SKU: | A01642-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, WB |
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Product info
Product Name
Anti-TYK2 Antibody
SKU/Catalog Number
A01642-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-TYK2 Antibody (Catalog # A01642-1). Tested in ELISA, WB, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
TYK2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Cite This Product
Anti-TYK2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01642-1)
Host
Rabbit
Contents
TYK2 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Rabbit polyclonal TYK2 antibody was raised against a 17 amino acid peptide near the amino terminus of human TYK2. The immunogen is located within amino acids 90 - 140 of TYK2.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least three isoforms of TYK2 are known to exist; this antibody only detects the two longest isoforms.
Reactive Species
A01642-1 is reactive to TYK2 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
133650 MW
Background of TYK2
TYK2 is a member of the Janus kinases (JAKs) protein families. TYK2 associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits and is also a component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A01642-1 is guaranteed for ELISA, IF, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
TYK2 antibody can be used for detection of TYK2 by Western blot at 1 - 2 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of TYK2 in human small intestine tissue lysate with TYK2 antibody at (A) 1 and (B) 2 μg/mL
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Immunofluorescence of TYK2 in A549 cells with TYK2 Antibody at 20 μg/ml.
Protein Target Info & Infographic
Gene/Protein Information For TYK2 (Source: Uniprot.org, NCBI)
Gene Name
TYK2
Full Name
Non-receptor tyrosine-protein kinase TYK2
Weight
133650 MW
Superfamily
protein kinase superfamily
Alternative Names
JTK1, Non-receptor tyrosine-protein kinase TYK2 TYK2 IMD35, JTK1 tyrosine kinase 2 non-receptor tyrosine-protein kinase TYK2
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TYK2, check out the TYK2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TYK2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-TYK2 Antibody (A01642-1)
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