Product Info Summary
SKU: | A01642 |
---|---|
Size: | 100 µl |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | IHC |
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Product info
Product Name
Anti-TYK2(Ab-1054) Antibody
SKU/Catalog Number
A01642
Size
100 µl
Form
Liquid
Description
Boster Bio Anti-TYK2(Ab-1054) Antibody (Catalog # A01642). Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-TYK2(Ab-1054) Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01642)
Host
Rabbit
Contents
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Peptide sequence around aa.1052~1056 (H-E-Y-Y-R) derived from Human TYK2.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross reactivity with other proteins.
Reactive Species
A01642 is reactive to TYK2 in Human, Mouse, Rat
Applications
A01642 is guaranteed for IHC Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
133650 MW
Background of TYK2
TYK2 encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
Zheng H, et al. (2005) Mol Cell Proteomics. 4(6):721-730.
Gauzzi MC, et al. (1996) J Biol Chem. 271(34): 20494-20500.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Predicted MW: 140kd
Immunohistochemistry: 1:50~1:100
Validation Images & Assay Conditions
Click image to see more details
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using TYK2(Ab-1054) antibody A01642(left) or the same antibody preincubated with blocking peptide(right).
Protein Target Info & Infographic
Gene/Protein Information For TYK2 (Source: Uniprot.org, NCBI)
Gene Name
TYK2
Full Name
Non-receptor tyrosine-protein kinase TYK2
Weight
133650 MW
Superfamily
protein kinase superfamily
Alternative Names
EC 2.7.10; EC 2.7.10.2; JTK1; non-receptor tyrosine-protein kinase TYK2; Tyk2; tyrosine kinase 2 TYK2 IMD35, JTK1 tyrosine kinase 2 non-receptor tyrosine-protein kinase TYK2
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TYK2, check out the TYK2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TYK2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-TYK2(Ab-1054) Antibody (A01642)
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No publications found for A01642
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Customer Reviews
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Customer Q&As
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7 Customer Q&As for Anti-TYK2(Ab-1054) Antibody
Question
We are currently using anti-TYK2(Ab-1054) antibody A01642 for rat tissue, and we are content with the IHC results. The species of reactivity given in the datasheet says human, mouse, rat. Is it likely that the antibody can work on goat tissues as well?
Verified Customer
Verified customer
Asked: 2020-03-31
Answer
The anti-TYK2(Ab-1054) antibody (A01642) has not been validated for cross reactivity specifically with goat tissues, though there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in goat you can get your next antibody for free. Please contact me if I can help you with anything.
Boster Scientific Support
Answered: 2020-03-31
Question
Is a blocking peptide available for product anti-TYK2(Ab-1054) antibody (A01642)?
Verified Customer
Verified customer
Asked: 2019-09-10
Answer
We do provide the blocking peptide for product anti-TYK2(Ab-1054) antibody (A01642). If you would like to place an order for it please contact [email protected] and make a special request.
Boster Scientific Support
Answered: 2019-09-10
Question
Does A01642 anti-TYK2(Ab-1054) antibody work on parafin embedded sections? If so, which fixation method do you recommend we use (PFA, paraformaldehyde, other)?
Verified Customer
Verified customer
Asked: 2019-09-03
Answer
You can see on the product datasheet, A01642 anti-TYK2(Ab-1054) antibody as been tested on IHC. It is best to use PFA for fixation because it has better tissue penetration ability. PFA needs to be prepared fresh before use. Long term stored PFA turns into formalin, as the PFA molecules congregate and become formalin.
Boster Scientific Support
Answered: 2019-09-03
Question
you antibody to test anti-TYK2(Ab-1054) antibody A01642 on mouse cervix carcinoma for research purposes, then I may be interested in using anti-TYK2(Ab-1054) antibody A01642 for diagnostic purposes as well. Is the antibody suitable for diagnostic purposes?
Verified Customer
Verified customer
Asked: 2019-06-03
Answer
The products we sell, including anti-TYK2(Ab-1054) antibody A01642, are only intended for research use. They would not be suitable for use in diagnostic work. If you have the means to develop a product into diagnostic use, and are interested in collaborating with us and develop our product into an IVD product, please contact us for more discussions.
Boster Scientific Support
Answered: 2019-06-03
Question
I have attached the WB image, lot number and protocol we used for cervix carcinoma using anti-TYK2(Ab-1054) antibody A01642. Please let me know if you require anything else.
K. Baker
Verified customer
Asked: 2019-05-02
Answer
Thank you very much for the data. Our lab team are working to resolve this as quickly as possible, and we appreciate your patience and understanding! You have provided everything we needed. Please let me know if there is anything you need in the meantime.
Boster Scientific Support
Answered: 2019-05-02
Question
Would anti-TYK2(Ab-1054) antibody A01642 work on goat IHC with cervix carcinoma?
M. Jackson
Verified customer
Asked: 2017-08-08
Answer
Our lab technicians have not tested anti-TYK2(Ab-1054) antibody A01642 on goat. You can run a BLAST between goat and the immunogen sequence of anti-TYK2(Ab-1054) antibody A01642 to see if they may cross-react. If the sequence homology is close, then you can perform a pilot test. Keep in mind that since we have not validated goat samples, this use of the antibody is not covered by our guarantee. However we have an innovator award program that if you test this antibody and show it works in goat cervix carcinoma in IHC, you can get your next antibody for free.
Boster Scientific Support
Answered: 2017-08-08
Question
Is this A01642 anti-TYK2(Ab-1054) antibody reactive to the isotypes of TYK2?
Verified Customer
Verified customer
Asked: 2017-05-23
Answer
The immunogen of A01642 anti-TYK2(Ab-1054) antibody is Peptide sequence around aa.1052~1056 (H-E-Y-Y-R) derived from Human TYK2. Could you tell me which isotype you are interested in so I can help see if the immunogen is part of this isotype?
Boster Scientific Support
Answered: 2017-05-23