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Product Info Summary
| SKU: | A04167-2 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Mouse |
| Host: | Rabbit |
| Application: | ELISA, IF, WB |
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Product info
Product Name
Anti-TSLP Receptor Crlf2 Antibody
View all TSLPR/CRLF2 Antibodies
SKU/Catalog Number
A04167-2
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-TSLP Receptor Crlf2 Antibody (Catalog # A04167-2). Tested in ELISA, WB, IF applications. This antibody reacts with Mouse.
Storage & Handling
TSLP Receptor antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-TSLP Receptor Crlf2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A04167-2)
Host
Rabbit
Contents
TSLP Receptor Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
TSLP receptor antibody was raised against a 21 amino acid synthetic peptide from near the center of mouse TSLP receptor. The immunogen is located within amino acids 140 - 190 of TSLP Receptor.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least two isoforms of TSLP-R are known to exist; this antibody will recognize both isoforms.
Reactive Species
A04167-2 is reactive to CRLF2 in Mouse
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
37762 MW
Background of TSLPR/CRLF2
Thymic stromal lymphopoietin (TSLP) has recently been identified as an important factor capable of driving dendritic cell maturation and activation. It is involved in the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and the induction of CD4+ T cell-mediated allergic reaction. TSLP is also capable of supporting the growth of fetal liver and adult B cell progenitors and their differentiation to the IgM-positive stage of B cell development. Its receptor TSLP-R will bind TSLP in a low-affinity fashion in transfected cells; co-transfection with IL-7R-alpha cDNA results in high-affinity binding and a functional heteromeric complex. This heteromeric receptor requires stat5 for TSLP-mediated signal transduction and is inhibited by SOCS-1. The approximately 75 kDa band seen in the immunoblot may be a post-translationally modified form of TSLP-R.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A04167-2 is guaranteed for ELISA, IF, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
TSLP receptor antibody can be used for detection of TSLP receptor by Western blot at 1 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of TSLP Receptor in mouse heart tissue lysate with TSLP Receptor antibody at 1 μg/mL in (A) the presence and (B) the absence of blocking peptide.
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Immunofluorescence of TSLP Receptor in Mouse Liver cells with TSLP Receptor antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For CRLF2 (Source: Uniprot.org, NCBI)
Gene Name
CRLF2
Full Name
Cytokine receptor-like factor 2
Weight
37762 MW
Superfamily
type I cytokine receptor family
Alternative Names
CRLM2, Ly114, Tpte2, Tslpr, Crlm2, Cytokine receptor-like factor 2, Cytokine receptor-like molecule 2, CRLM-2 Crlf2|CRLM2, Ly11, Ly114, T, Tpte, Tpte2, Tslpr|cytokine receptor-like factor 2|cytokine receptor-like factor 2|TSLP receptor|cytokine receptor-like molecule 2|lymphocyte 114|thymic stromal lymphopoietin protein receptor|thymic stromal-derived lymphopoietin, receptor|transmembrane phosphoinositide 3-phosphatase and tensin homolog 2|type I cytokine receptor delta 1
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on CRLF2, check out the CRLF2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for CRLF2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-TSLP Receptor Crlf2 Antibody (A04167-2)
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