Anti-TSLP Receptor Crlf2 Antibody

Product Name

Anti-TSLP Receptor Crlf2 Antibody

View all TSLPR/CRLF2 Antibodies

SKU/Catalog Number

A04167-2

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-TSLP Receptor Crlf2 Antibody (Catalog # A04167-2). Tested in ELISA, WB, IF applications. This antibody reacts with Mouse.

Storage & Handling

TSLP Receptor antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-TSLP Receptor Crlf2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A04167-2)

Host

Rabbit

Contents

TSLP Receptor Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

TSLP receptor antibody was raised against a 21 amino acid synthetic peptide from near the center of mouse TSLP receptor. The immunogen is located within amino acids 140 - 190 of TSLP Receptor.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

At least two isoforms of TSLP-R are known to exist; this antibody will recognize both isoforms.

Reactive Species

A04167-2 is reactive to Crlf2 in Mouse

Applications

A04167-2 is guaranteed for ELISA, IF, WB Boster Guarantee

Observed Molecular Weight

68 kDa

Calculated molecular weight

37762 MW

Background of TSLPR/CRLF2

Thymic stromal lymphopoietin (TSLP) has recently been identified as an important factor capable of driving dendritic cell maturation and activation. It is involved in the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and the induction of CD4+ T cell-mediated allergic reaction. TSLP is also capable of supporting the growth of fetal liver and adult B cell progenitors and their differentiation to the IgM-positive stage of B cell development. Its receptor TSLP-R will bind TSLP in a low-affinity fashion in transfected cells; co-transfection with IL-7R-alpha cDNA results in high-affinity binding and a functional heteromeric complex. This heteromeric receptor requires stat5 for TSLP-mediated signal transduction and is inhibited by SOCS-1. The approximately 75 kDa band seen in the immunoblot may be a post-translationally modified form of TSLP-R.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

TSLP receptor antibody can be used for detection of TSLP receptor by Western blot at 1 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

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Western blot analysis of TSLP Receptor in mouse heart tissue lysate with TSLP Receptor antibody at 1 μg/mL in (A) the presence and (B) the absence of blocking peptide.

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Immunofluorescence of TSLP Receptor in Mouse Liver cells with TSLP Receptor antibody at 20 μg/mL.

Gene/Protein Information For Crlf2 (Source: Uniprot.org, NCBI)

Alternative Names

CRL2; CRL2cytokine receptor CRL2 precusor; CRLF2; CRLF2Y; CRLM-2; Cytokine receptor-like 2; cytokine receptor-like factor 2; ILXR; IL-XR; P2RY8/CRLF2 fusion; PCOR1; Thymic stromal lymphopoietin protein receptor; thymic stromal lymphopoietin receptor; thymic stromal-derived lymphopoietin receptor; TSLP R; TSLP receptor; TSLPR Crlf2|CRLM2, Ly11, Ly114, T, Tpte, Tpte2, Tslpr|cytokine receptor-like factor 2|cytokine receptor-like factor 2|TSLP receptor|cytokine receptor-like molecule 2|lymphocyte antigen 114|thymic stromal lymphopoietin protein receptor|thymic stromal-derived lymphopoietin, receptor|transmembrane phosphoinositide 3-phosphatase and tensin homolog 2|type I cytokine receptor delta 1

For more info on Crlf2, check out the Crlf2 Infographic

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In this infographic, you will see the following information for Crlf2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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