TRIO Antibodies

AND TRIO ELISA kits, TRIO Proteins

Many biological assays use antibodies to detect TRIO, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TRIO in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TRIO antibodies...

We validate the specificity of these antibodies to TRIO by testing them on tissues known to express TRIO positively and negatively. Browse below to find the TRIO antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TRIO Infographic by Boster Bio

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Anti-TRIO Antibody

Human, Mouse

IHC

$380
Cat # A00679
100ul

TRIO Overview

Facts about Triple functional domain protein.

Triple functional domain protein (TRIO)

Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:8643598, PubMed:27418539). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202).

In developing hippocampal neurons, limits dendrite formation, without affecting the institution of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) in CA1 excitatory synapses (By similarity).

Gene Information

Human
Gene Name:	TRIO
Uniprot:	O75962
Entrez:	7204

Family

Belongs to:

protein kinase superfamily

Alternative Names

ARHGEF23; EC 2.7.11.1; FLJ42780; PTPRF-interacting protein; tgat; triple functional domain (PTPRF interacting); triple functional domain protein

Molecular Weight

Mass (kDA):
346.9 kDA

Genomic Context


Human

Location:	5p15.2
Sequence:	5; NC_000005.10 (14143342..14510204)

Tissue Specificity

Widely expressed, with highest levels in heart, skeletal muscle, and brain.

Subcellular Localizations

Cytoplasm. Cell projection.

Diseases

Malignant Neoplasms
Neoplasms
Apnea
Tissue Adhesions
Carcinoma
Nervousness
Hiv Infections
Tumor Progression
Cell Invasion
Neoplasm Invasiveness
Cell Transformation, Neoplastic
Malignant Squamous Cell Neoplasm
Leukemia

Ataxia
Malignant Neoplasm Of Urinary Bladder
Sarcoma
Immunologic Deficiency Syndromes
Dysplasia
Malignant Paraganglionic Neoplasm
Dysbarism

Interacting Proteins

DISC1

Pathways

Axon Guidance
Cell Migration
Localization
Pathogenesis
Transport
Actin Cytoskeleton Reorganization
Gas Transport
Cell Growth
Axon Extension
Segmentation
Myoblast Fusion
Cell Proliferation
Axonogenesis

Locomotion
Rna Interference
Cell Adhesion
Dorsal Closure
Neurogenesis
Cytokinesis
Cell Fate Specification

PTMs

Phosphorylation
Ribosylation

Cleavage
Amidation

Prenylation

Research Areas

Protein Kinase

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRIO

References

PMID: 8643598 by Debant A., et al. The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac- specific and rho-specific guanine nucleotide exchange factor domains.

PMID: 10341202 by Seipel K., et al. Trio amino-terminal guanine nucleotide exchange factor domain expression promotes actin cytoskeleton reorganization, cell migration and anchorage-independent cell growth.