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Product Info Summary
| SKU: | A12951 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-Transmembrane protein 88 TMEM88 Antibody
SKU/Catalog Number
A12951
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Transmembrane protein 88 TMEM88 Antibody (Catalog # A12951). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
TMEM88 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Transmembrane protein 88 TMEM88 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A12951)
Host
Rabbit
Contents
TMEM88 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
TMEM88 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human TMEM88. The immunogen is located within amino acids 110 - 160 of TMEM88.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least two isoforms of TMEM88 are known to exist; this antibody will recognize both isoforms.
Reactive Species
A12951 is reactive to TMEM88 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
17251 MW
Background of Tmem88
Transmembrane protein 88 (TMEM88) is a two-transmembrane-type protein whose C-terminal tail has been shown to bind the PDZ domain of Dishevelled (Dvl), one of the key components in Wnt signaling pathways. TMEM88 attentuated the Wnt/beta-catenin signaling induced by Wnt-1 ligand in a dose-dependent manner and knockdown of TMEM88 by RNAi increased Wnt activity, suggesting that TMEM88 plays a role in regulating Wnt signaling in a context-dependent manner.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A12951 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
TMEM88 antibody can be used for detection of TMEM88 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of TMEM88 in human brain tissue lysate with TMEM88 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
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Immunohistochemistry of TMEM88 in mouse brain tissue with TMEM88 antibody at 2.5 μg/mL.
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Immunofluorescence of TMEM88 in mouse brain tissue with TMEM88 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For TMEM88 (Source: Uniprot.org, NCBI)
Gene Name
TMEM88
Full Name
Transmembrane protein 88
Weight
17251 MW
Superfamily
TMEM88 family
Alternative Names
TMEM88A, Transmembrane protein 88
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TMEM88, check out the TMEM88 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TMEM88: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Transmembrane protein 88 TMEM88 Antibody (A12951)
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