Product Info Summary
SKU: | M01610 |
---|---|
Size: | 0.1 mg |
Reactive Species: | Human, Mouse, Rat |
Host: | Mouse |
Application: | ELISA, IP, IHC-P, ICC, WB |
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Product info
Product Name
Anti-TPX2 Purified Monoclonal Antibody
SKU/Catalog Number
M01610
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-TPX2 Purified Monoclonal Antibody (Catalog# M01610). Tested in IP, WB, IHC-P, ICC, ELISA application(s). This antibody reacts with Rat, Mouse, Human.
Storage & Handling
Store at 2-8°C. Do not freeze.
Cite This Product
Anti-TPX2 Purified Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M01610)
Host
Mouse
Contents
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Clonality
Monoclonal
Clone Number
TPX2-01
Isotype
Mouse IgG1
Immunogen
Human TPX2. The mouse monoclonal antibody TPX2-01 recognizes the epitope EPFVPKKEKKS (aa 636-646 in human) of TPX2, a microtubule-associated intracellular critical regulator of mitosis, which is overexpressed in many types of tumors and is a marker of worse prognosis in various cancers.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
M01610 is reactive to TPX2 in Human, Mouse, Rat
Applications
M01610 is guaranteed for ELISA, IP, IHC-P, ICC, WB Boster Guarantee
Observed Molecular Weight
42 kDa
Calculated molecular weight
85653 MW
Background of TPX2
TPX2 is a microtubule-associated protein, which is a critical regulator of mitosis. At the beginning of mitosis, TPX2 is released and plays a significant role in mitotic spindle formation and subsequent proper segregation of chromosomes during cell division. After completion of mitosis the TPX2 protein disappears, but has also role in DNA damage response. Its overexpression has been demonstrated in many types of carcinomas. TPX2 belongs to the markers of worse tumor prognosis. On the other hand, down-regulation of TPX2 can inhibit cancer cell proliferation, migration and invasion.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Flow cytometry: 1-4 μg/ml.
Validation Images & Assay Conditions
Click image to see more details
Figure 1. Immunohistochemistry validation of TPX2 using Anti-TPX2 Purified Monoclonal Antibody (M01610).
Immunocytochemistry of TPX2 using monoclonal antibody TPX2-01 in glioblastoma cell line T98G: a) interphaseClick image to see more details
Figure 2. IP validation of TPX2 using Anti-TPX2 Purified Monoclonal Antibody (M01610).
Immunoprecipitation of TPX2 from nuclear extract of HEK293 cells using monoclonal antibody TPX2-01. 1) nuclear extractClick image to see more details
Figure 3. Western blotting validation for Anti-TPX2 Purified Monoclonal Antibody M01610
Western blotting analysis of TPX2 using monoclonal antibody TPX2-01 in A) human cell linesProtein Target Info & Infographic
Gene/Protein Information For TPX2 (Source: Uniprot.org, NCBI)
Gene Name
TPX2
Full Name
Targeting protein for Xklp2
Weight
85653 MW
Superfamily
TPX2 family
Alternative Names
C20orf1HCTP4; C20orf2; chromosome 20 open reading frame 1; Differentially expressed in cancerous and non-cancerous lung cells 2; differentially expressed in lung cells; DIL2; DIL-2FLS353; HCA519; Hepatocellular carcinoma-associated antigen 519; P100; p100GD:C20orf1; preferentially expressed in colorectal cancer; Protein fls353; REPP86; restricted expression proliferation associated protein 100; Restricted expression proliferation-associated protein 100; targeting protein for Xklp2; TPX2, microtubule-associated protein homolog; TPX2, microtubule-associated, homolog (Xenopus laevis) TPX2 C20orf1, C20orf2, DIL-2, DIL2, FLS353, GD:C20orf1, HCA519, HCTP4, REPP86, p100 TPX2 microtubule nucleation factor targeting protein for Xklp2|TPX2, microtubule-associated protein homolog|TPX2, microtubule-associated, homolog|differentially expressed in cancerous and non-cancerous lung cells 2|differentially expressed in lung cells|hepatocellular carcinoma-associated antigen 519|hepatocellular carcinoma-associated antigen 90|preferentially expressed in colorectal cancer|protein fls353|restricted expression proliferation associated protein 100
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TPX2, check out the TPX2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TPX2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-TPX2 Purified Monoclonal Antibody (M01610)
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