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TPX2 Antibodies
AND TPX2 ELISA kits, TPX2 Proteins
Many biological assays use antibodies to detect TPX2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TPX2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TPX2 antibodies...
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TPX2 Infographic by Boster Bio
All TPX2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, IP, IHC-P, ICC, WB
$323
Cat # M01610
0.1 mg
Cat # M01610
0.1 mg
TPX2 Overview
Facts about Targeting protein for Xklp2.
Targeting protein for Xklp2 (TPX2)
Spindle assembly factor necessary for normal assembly of mitotic spindles. Required for regular assembly of microtubules during apoptosis.
Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764).
Gene Information
| Human | |
|---|---|
| Gene Name: | TPX2 |
| Uniprot: | Q9ULW0 |
| Entrez: | 22974 |
Family
| Belongs to: |
|---|
| TPX2 family |
Alternative Names
C20orf1HCTP4; C20orf2; chromosome 20 open reading frame 1; Differentially expressed in cancerous and non-cancerous lung cells 2; differentially expressed in lung cells; DIL2; DIL-2FLS353; HCA519; Hepatocellular carcinoma-associated antigen 519; P100; p100GD:C20orf1; preferentially expressed in colorectal cancer; Protein fls353; REPP86; restricted expression proliferation associated protein 100; Restricted expression proliferation-associated protein 100; targeting protein for Xklp2; TPX2, microtubule-associated protein homolog; TPX2, microtubule-associated, homolog (Xenopus laevis)
Molecular Weight
Mass (kDA):
85.653 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 20q11.21 |
| Sequence: | 20; NC_000020.11 (31739248..31801802) |
Tissue Specificity
Expressed in lung carcinoma cell lines but not in normal lung tissues.
Subcellular Localizations
Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Cell Transformation, Neoplastic
- Aneuploidy
- Carcinogenesis
- Lung Neoplasms
- Malignant Paraganglionic Neoplasm
- Lymphoma
- Adenocarcinoma
- Malignant Neoplasm Of Lung
- Malignant Neoplasm Of Pancreas
- Malignant Neoplasm Of Ovary
Interacting Proteins
- AURKA
- GOLGA2
- GRB2
- HMMR
- NCK1
- PIK3R1
Pathways
- Spindle Assembly
- Mitosis
- Cell Division
- Cell Cycle
- Localization
- Interphase
- Microtubule Nucleation
- Chromosome Segregation
- Rna Interference
- Cell Proliferation
- Cytokinesis
- Anaphase
- Meiosis
PTMs
- Phosphorylation
- Dephosphorylation
- Cleavage
Research Areas
- Cancer
- Cell Biology
- Cell Cycle and Replication
- Chromatin Research
- DNA Repair
- Mitotic Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TPX2
bosterbio.com/bosterbio-gene-info-cards/TPX2
References
PMID: 10512675 by Manda R., et al. Identification of genes (SPON2 and C20orf2) differentially expressed between cancerous and noncancerous lung cells by mRNA differential display.
PMID: 10393424 by Zhang Y., et al. Assignment of human proliferation associated p100 gene (C20orf1) to human chromosome band 20q11.2 by in situ hybridization.