Anti-TP1 TEP1 Antibody

Product Name

Anti-TP1 TEP1 Antibody

View all TEP1 Antibodies

SKU/Catalog Number

A02017

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-TP1 TEP1 Antibody (Catalog # A02017). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

TP1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-TP1 TEP1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02017)

Host

Rabbit

Contents

TP1 Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

TP1 antibody was raised against a 20 amino acid synthetic peptide from near the amino terminus of human TP1. The immunogen is located within the first 50 amino acids of TP1.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

SRPK1 antibody is human, mouse and rat reactive. Multiple isoforms of SRPK1 are known to exist; this antibody will detect all except isoforms b and e. SRPK1 antibody is predicted to not cross-react with SRPK2.

Reactive Species

A02017 is reactive to TEP1 in Human, Mouse, Rat

Applications

A02017 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee

Observed Molecular Weight

68 kDa

Calculated molecular weight

290490 MW

Background of TEP1

Telomerase is an RNA-dependent DNA polymerase that uses an RNA component to add telomeric repeat sequences at the ends of chromosomes. Besides the RNA component which serves as the template that specifies the telomeric repeat, the telomerase complex contains a reverse transcriptase protein (TRT) and various accessory proteins including the telomerase-associated protein 1 (TP1). Telomerase activity is low in most somatic cells, causing the gradual shortening of telomeres which can ultimately lead to telomere fusion and cell death. High levels of telomerase activity are widely seen in cancerous cells and while recent experiments have suggested that telomerase may be a viable target in cancer therapy, expression levels of TP1 do not correlate with malignancy. At least two isoforms of TP1 are known to exist.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

TP1 antibody can be used for detection of TP1 by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

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Western blot analysis of TP1 in human kidney tissue lysate with TP1 antibody at (A) 0.5 and (B) 1 μg/mL.

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Immunohistochemical staining of human lung tissue using TP1 antibody at 2.5 μg/mL.

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Immunofluorescence of TP-1 in Human Lung cells with TP-1 antibody at 20 μg/mL.

Gene/Protein Information For TEP1 (Source: Uniprot.org, NCBI)

Alternative Names

p240telomerase protein component 1; telomerase-associated protein 1VAULT2; TLP1p80 telomerase homolog; TP1Telomerase protein 1; TROVE domain family, member 1; TROVE1 TEP1 TLP1, TP1, TROVE1, VAULT2, p240 telomerase associated protein 1 telomerase protein component 1|TROVE domain family, member 1|p80 telomerase homolog|telomerase protein 1

For more info on TEP1, check out the TEP1 Infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for TEP1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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