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TEP1 Antibodies
AND TEP1 ELISA kits, TEP1 Proteins
Many biological assays use antibodies to detect TEP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TEP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TEP1 antibodies...
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TEP1 Overview
Facts about Telomerase protein component 1.
Telomerase protein component 1 (TEP1)
Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini (PubMed:19179534). Additionally component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport (By similarity).
Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | TEP1 |
| Uniprot: | Q99973 |
| Entrez: | 7011 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
p240telomerase protein component 1; telomerase-associated protein 1VAULT2; TLP1p80 telomerase homolog; TP1Telomerase protein 1; TROVE domain family, member 1; TROVE1
Molecular Weight
Mass (kDA):
290.49 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 14q11.2 |
| Sequence: | 14; NC_000014.9 (20365667..20413540, complement) |
Subcellular Localizations
Nucleus. Chromosome, telomere.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Malignant Paraganglionic Neoplasm
- Cell Transformation, Neoplastic
- Malaria
- Carcinogenesis
- Hamartoma Syndrome, Multiple
- Malignant Neoplasm Of Breast
- Neoplasm Metastasis
- Glioblastoma
- Hamartoma
- Glioma
Pathways
- Cell Growth
- Cell Cycle
- Cell Proliferation
- Pathogenesis
- Transport
- Localization
- Cell Cycle Arrest
- Senescence
- Cell Death
- Immune Response
- Oncogenesis
- Reverse Transcription
- Telomere Maintenance
PTMs
- Phosphorylation
- Dephosphorylation
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TEP1
bosterbio.com/bosterbio-gene-info-cards/TEP1
References
PMID: 9020079 by Harrington L., et al. A mammalian telomerase-associated protein.
PMID: 9389643 by Harrington L., et al. Human telomerase contains evolutionarily conserved catalytic and structural subunits.