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Product Info Summary
| SKU: | A07234 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-TMP21 TMED10 Antibody
SKU/Catalog Number
A07234
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-TMP21 TMED10 Antibody (Catalog # A07234). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
TMP21 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-TMP21 TMED10 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A07234)
Host
Rabbit
Contents
TMP21 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
TMP21 antibody was raised against a 19 amino acid synthetic peptide from near the carboxy terminus of human TMP21. The immunogen is located within amino acids 160 - 210 of TMP21.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
TTYH1 antibody is human specific. Multiple isoforms of TTYH1 are known to exist.
Reactive Species
A07234 is reactive to TMED10 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
24976 MW
Background of Tmp21/p23
TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the gamma-secretase but not the epsilon-secretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the gamma- and epsilon-sites and can lead to the accumulation of the Abeta cleavage product that is associated with Alzheimer's disease. Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21 indicating that TMP21 may play a role in the regulation of this complex. Suppression of TMP21 expression by siRNA in transfected cells caused increased gamma-secretase activity but not epsilon-secretase activity, and increased Abeta production, demonstrating that TMP21 can modulate gamma-secretase activity.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A07234 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
TMP21 antibody can be used for detection of TMP21 by Western blot at 0.5 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of TMP21 in Raji cell lysate with TMP21 antibody at (A) 0.5 and (B) 1 and (C) 2 μg/mL.
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Immunohistochemistry of TMP21 in human brain tissue with TMP21 antibody at 2.5 μg/mL.
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Immunofluorescence of TMP21 in Human Brain cells with TMP21 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For TMED10 (Source: Uniprot.org, NCBI)
Gene Name
TMED10
Full Name
Transmembrane emp24 domain-containing protein 10
Weight
24976 MW
Superfamily
EMP24/GP25L family
Alternative Names
p23, TMP21, S31I125, Tmp-21-I, S31III125, P24(DELTA), Transmembrane emp24 domain-containing protein 10, 21 kDa transmembrane-trafficking protein TMED10 P24(DELTA), S31I125, S31III125, TMP21, Tmp-21-I, p23, p24d1 transmembrane p24 trafficking protein 10 transmembrane emp24 domain-containing protein 10|21 kDa transmembrane trafficking protein|p24 family protein delta-1|p24delta|p24delta1|testicular tissue protein Li 206|transmembrane emp24-like trafficking protein 10|transmembrane protein Tmp21
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TMED10, check out the TMED10 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TMED10: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-TMP21 TMED10 Antibody (A07234)
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