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Product Info Summary
| SKU: | M07131 |
|---|---|
| Size: | 100ug |
| Reactive Species: | Human |
| Host: | Mouse |
| Application: | ELISA, IHC |
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Product info
Product Name
Anti-TIMP4 Monoclonal Antibody
SKU/Catalog Number
M07131
Size
100ug
Form
Liquid (sterile filtered)
Description
Boster Bio Anti-TIMP4 Monoclonal Antibody (Catalog # M07131). Tested in ELISA, IHC applications. This antibody reacts with Human.
Storage & Handling
Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening. (Ship on dry ice.)
Cite This Product
Anti-TIMP4 Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M07131)
Host
Mouse
Contents
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2, 0.01% (w/v) Sodium Azide
Clonality
Monoclonal
Clone Number
Clone: 9:4-7 IgG2b kappa
Isotype
IgG2b kappa
Immunogen
Anti-TIMP4 (MOUSE) Monoclonal Antibody was produced in mouse by repeated immunizations with full length human TIMP4 protein followed by hybridoma development.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
M07131 is reactive to TIMP4 in Human
Reconstitution
Calculated molecular weight
25503 MW
Background of TIMP-4
Tissue inhibitor of metalloproteinase-4 (TIMP-4) is member of the TIMP family of inhibitors of matrix metalloproteinase (MMP) activities. In addition, TIMPs have non-MMP associated functions, including roles in growth promotion, apoptosis, and angiogenesis. All four members of the TIMP gene family form a similar secondary structure due to the formation of six highly conserved disulfide bonds. It has been reported that some TIMPs, TIMP4 included, can bind a tetraspanin in the plasma membrane, initiating an intra-cellular signaling cascade. Elevated levels of TIMP4 have been associated with breast cancer progression and heart disease.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
M07131 is guaranteed for ELISA, IHC Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
ELISA: 1:20,000 - 1:100,000
IHC: 5-10µg/mL
WB: 1:2,000 to 1:10,000
Validation Images & Assay Conditions
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TMIP4 was detected in paraffin-embedded sections of kidney tissues using mouse anti-TMIP4 monoclonal antibody (Catalog # M07131) at 10 μg/mL. Secondary antibody: Peroxidase mouse secondary antibody at 1:10,000 for 45 min at RT. Staining: TMIP4 as precipitated red signal with hematoxylin purple nuclear counterstain.
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TMIP4 was detected in paraffin-embedded sections of human mammary cancer tissues. Primary antibody: a) isotype specific IgG2bk monoclonal; b) TIMP-4 antibody (clone 9:4-7) (Catalog # M07131); and c) TIMP-4 each at 10 µg/mL. Secondary antibody: Peroxidase mouse secondary antibody at 1:10,000 for 45 min at RT. Localization: TIMP-4 is secreted. Staining: TIMP-4 as precipitated brown signal. using mouse anti-TMIP4 monoclonal antibody (Catalog # M07131) at 10 μg/mL.
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TMIP4 was detected in paraffin-embedded sections of small intestine tissues using mouse anti-TMIP4 monoclonal antibody (Catalog # M07131) at 10 μg/mL. Secondary antibody: Peroxidase mouse secondary antibody at 1:10,000 for 45 min at RT. Staining: TMIP4 as precipitated red signal with hematoxylin purple nuclear counterstain.
Protein Target Info & Infographic
Gene/Protein Information For TIMP4 (Source: Uniprot.org, NCBI)
Gene Name
TIMP4
Full Name
Metalloproteinase inhibitor 4
Weight
25503 MW
Superfamily
protease inhibitor I35 (TIMP) family
Alternative Names
TIMP4, Tissue inhibitor of metalloproteinase-4, Metalloproteinase inhibitor 4, TIMP-4, TIMP 4, TIMP4, anti-TIMP-4 TIMP4 TIMP-4 TIMP metallopeptidase inhibitor 4 metalloproteinase inhibitor 4|tissue inhibitor of metalloproteinase 4|tissue inhibitor of metalloproteinases 4
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TIMP4, check out the TIMP4 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TIMP4: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-TIMP4 Monoclonal Antibody (M07131)
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No publications found for M07131
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