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Product Info Summary
| SKU: | A00191 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-TET2 Antibody
SKU/Catalog Number
A00191
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-TET2 Antibody (Catalog # A00191). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.
Storage & Handling
TET2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-TET2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00191)
Host
Rabbit
Contents
TET2 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
TET2 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human TET2. The immunogen is located within amino acids 20 - 70 of TET2.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least two isoforms of TET2 are known to exist; this antibody will detect both isoforms.
Reactive Species
A00191 is reactive to TET2 in Human
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
223811 MW
Background of TET2
TET2, a member of the ten-eleven-translocation (TET) family of genes, is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. It is a candidate tumor suppressor gene reported to be mutated in approximately 14% of patients with JAK2V617F-positive myeloproliferative neoplasms, and can be mutated in other hematopoietic disorders such as myelodysplastic syndromes, acute myeloid leukemia, and chronic myelomonocytic leukemia. Analysis of the TET2 and JAK2 mutations in these neoplasms suggests that mutations in TET2 do not represent a predisposition for acquiring mutations in JAK2.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A00191 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
TET2 antibody can be used for detection of TET2 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of TET2 in SK-N-SH cell lysate with TET2 antibody at 1 μg/mL.
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Immunohistochemistry of TET2 in human colon carcinoma tissue with TET2 antibody at 2 μg/ml.
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Immunofluorescence of TET2 in human colon carcinoma tissue with TET2 antibody at 20 μg/ml.
Green: TET2 Antibody (A00191)
Blue: DAPI staining
Protein Target Info & Infographic
Gene/Protein Information For TET2 (Source: Uniprot.org, NCBI)
Gene Name
TET2
Full Name
Methylcytosine dioxygenase TET2
Weight
223811 MW
Superfamily
TET family
Alternative Names
MDS, KIAA1546, Nbla00191, Methylcytosine dioxygenase TET2 TET2 IMD75, KIAA1546, MDS tet methylcytosine dioxygenase 2 methylcytosine dioxygenase TET2|probable methylcytosine dioxygenase TET2|ten-eleven translocation 2|tet oncogene family member 2
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TET2, check out the TET2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TET2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-TET2 Antibody (A00191)
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