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Product Info Summary
| SKU: | A08584-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-TEM7 PLXDC1 Antibody
View all TEM7/PLXDC1 Antibodies
SKU/Catalog Number
A08584-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-TEM7 PLXDC1 Antibody (Catalog # A08584-1). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
TEM7 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-TEM7 PLXDC1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A08584-1)
Host
Rabbit
Contents
TEM7 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
TEM7 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human TEM7. The immunogen is located within the last 50 amino acids of TEM7.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
NDST2 antibody is human, mouse and rat reactive. At least two isoforms of NDST2 are known to exist; this antibody will only detect the larger isoform. NDST2 antibody is predicted not to cross-react with other members of the NDST protein family.
Reactive Species
A08584-1 is reactive to PLXDC1 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
55760 MW
Background of TEM7/PLXDC1
Tumor endothelial marker 7 (TEM7) was identified through serial analysis of gene expression on endothelial cells isolated from human normal and malignant colorectal tissues. Further experiments verified TEM7 was highly expressed in the endothelium of numerous other cancer types including breast, lung and brain tumors. At least four isoforms of TEM7 are known to exist; these include intracellular, secreted, and membrane-bound forms. A homologous protein, TEM7R (also known as PLXDC2), acts as a binding partner to TEM7 and is also abundantly expressed in the endothelium of malignant colorectal cancer but is absent or rare in normal colon mucosa. High expression of TEM7 is associated with metastasis and poor survival of patients with osteogenic sarcoma.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A08584-1 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
TEM7 antibody can be used for detection of TEM7 by Western blot at 0.5 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of TEM7 in human liver tissue lysate with TEM7 antibody at (A) 0.5
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Immunohistochemistry of TEM7 in mouse liver tissue with TEM7 antibody at 2.5 μg/mL.
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Immunofluorescence of TEM7 in mouse liver tissue with TEM7 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For PLXDC1 (Source: Uniprot.org, NCBI)
Gene Name
PLXDC1
Full Name
Plexin domain-containing protein 1
Weight
55760 MW
Superfamily
plexin family
Alternative Names
TEM3, TEM7, TEM3, Plexin domain-containing protein 1, Tumor endothelial marker 3 PLXDC1 TEM3, TEM7 plexin domain containing 1 plexin domain-containing protein 1|2410003I07Rik|tumor endothelial marker 3|tumor endothelial marker 7
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on PLXDC1, check out the PLXDC1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for PLXDC1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-TEM7 PLXDC1 Antibody (A08584-1)
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