This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Plexin domain-containing protein 1.
.
Human | |
---|---|
Gene Name: | PLXDC1 |
Uniprot: | Q8IUK5 |
Entrez: | 57125 |
Belongs to: |
---|
plexin family |
FLJ45632; plexin domain containing 1,2410003I07Rik; plexin domain-containing protein 1; PLXDC1; TEM3; TEM3FLJ36270; TEM7; TEM7DKFZp686F0937; Tumor endothelial marker 3; Tumor endothelial marker 7
Mass (kDA):
55.76 kDA
Human | |
---|---|
Location: | 17q12 |
Sequence: | 17; NC_000017.11 (39063313..39151637, complement) |
Detected in endothelial cells from colorectal cancer, and in endothelial cells from primary cancers of the lung, liver, pancreas, breast and brain. Not detectable in endothelial cells from normal tissue. Expressed in fibrovascular membrane with increased expression in individuals with proliferative diabetic retinopathy.
[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Localized predominantly at the tight junctions of vascular endothelial cells and to a lesser extent at the luminal surface of vascular endothelial cells.; [Isoform 2]: Secreted.; [Isoform 3]: Secreted.; [Isoform 4]: Cytoplasm.
PMID: 10947988 by St Croix B., et al. Genes expressed in human tumor endothelium.
PMID: 11559528 by Carson-Walter E.B., et al. Cell surface tumor endothelial markers are conserved in mice and humans.