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Product Info Summary
| SKU: | A09350 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-Tectonic-1 TCTN1 Antibody
SKU/Catalog Number
A09350
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Tectonic-1 TCTN1 Antibody (Catalog # A09350). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.
Storage & Handling
TCTN1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Tectonic-1 TCTN1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A09350)
Host
Rabbit
Contents
TCTN1 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
TCTN1 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human TCTN1. The immunogen is located within amino acids 30 - 80 of TCTN1.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Although antibody should react with both isoforms, only the Bcl-GS protein has been observed
Reactive Species
A09350 is reactive to TCTN1 in Human, Mouse
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
63570 MW
Background of TCTN1
TCTN1 is the founding member of the Tectonic protein family, a group of evolutionarily conserved secreted and transmembrane proteins that regulate the Hedgehog (Hh)-mediated patterning of the neural tube. During embryonic development, TCTN1 is expressed in regions that participate in Hh signaling, beginning in the gastrulation stages in the ventral node. Mice expressing mutant TCTN1 die between E13.5 and E16.5 and display holoprosencephaly, a defect associated with reduced Hh signaling, indicating the role of TCTN1 as an Hh activator. At later stages in development, TCTN1 is thought to also act as a repressor on the Hh pathway in the anterior and posterior neural tube.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A09350 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
TCTN1 antibody can be used for detection of TCTN1 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of TCTN1 in mouse kidney tissue lysate with TCTN1 antibody at (A) 1 and (B) 2μg/mL.
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Immunohistochemistry of TCTN1 in human kidney tissue with TCTN1 antibody at 5 μg/mL.
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Immunofluorescence of TCTN1 in Human Kidney cells with TCTN1 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For TCTN1 (Source: Uniprot.org, NCBI)
Gene Name
TCTN1
Full Name
Tectonic-1
Weight
63570 MW
Superfamily
tectonic family
Alternative Names
TECT1, JBTS13, TECT1, UNQ9369/PRO34160, Tectonic-1 TCTN1 JBTS13, TECT1 tectonic family member 1 tectonic-1
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TCTN1, check out the TCTN1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TCTN1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Tectonic-1 TCTN1 Antibody (A09350)
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