Anti-TCCR IL27RA Antibody

Product Name

Anti-TCCR IL27RA Antibody

View all IL-27R alpha/WSX-1/TCCR Antibodies

SKU/Catalog Number

A03654

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-TCCR IL27RA Antibody (Catalog # A03654). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.

Storage & Handling

TCCR antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-TCCR IL27RA Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03654)

Host

Rabbit

Contents

TCCR Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

TCCR antibody was raised against a synthetic peptide corresponding to amino acids near the amino terminus of human TCCR precursor. The immunogen is located within the first 50 amino acids of TCCR.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

At least three isoforms of KIF5 are known to exist; this antibody will recognize all three isoforms.

Reactive Species

A03654 is reactive to IL27RA in Human

Reconstitution

Observed Molecular Weight

68 kDa

Calculated molecular weight

69474 MW

Background of IL-27R alpha/WSX-1/TCCR

Upon antigen challenge, T-helper cells differentiate into two functional distinct subsets, Th1 and Th2. Th1 cells produce IL-2, IFN-gamma and lymphotoxin-beta that augment cell mediated immune response while Th2 cells secrete IL-4, IL-5, and IL-10 that enhance humoral immunity. The function of T-helper cells is regulated by cytokines. A novel cytokine receptor was recently identified and cloned. It is a new member in the type I cytokine receptor family and designated TCCR for T-cell cytokine receptor and WSX-1. TCCR deficient mice had impaired Th1 responses to protein antigen challenge, including decreased levels of IFN-gamma and Th1-dependent antibody IgG2a. TCCR is predominately expressed in thymus, spleen, lymph notes and peripheral blood leukocytes.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A03654 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

TCCR antibody can be used for detection of TCCR by Western blot at 1 μg/mL. An approximately 70 kDa band can be detected. Antibody can also be used for immunohistochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

Gene/Protein Information For IL27RA (Source: Uniprot.org, NCBI)

Alternative Names

CRL1, TCCR, WSX1, IL27R, IL-27RA, zcytor1, CRL1, UNQ296/PRO336, Interleukin-27 receptor subunit alpha, Cytokine receptor WSX-1, IL-27 receptor subunit alpha IL27RA CRL1, IL-27RA, IL27R, TCCR, WSX1, zcytor1 interleukin 27 receptor subunit alpha interleukin-27 receptor subunit alpha|IL-27 receptor subunit alpha|IL-27R subunit alpha|IL-27R-alpha|T-cell cytokine receptor type 1|class I cytokine receptor|cytokine receptor WSX-1|cytokine receptor-like 1|interleukin 27 receptor, alpha|type I T-cell cytokine receptor

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

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