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IL27RA Antibodies
AND IL27RA ELISA kits, IL27RA Proteins
Many biological assays use antibodies to detect IL27RA, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with IL27RA in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop IL27RA antibodies...
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IL27RA Overview
Facts about Interleukin-27 receptor subunit alpha.
Interleukin-27 receptor subunit alpha (IL27RA)
Receptor for IL27.
Requires IL6ST/gp130 to mediate signal transduction in response to IL27.This signaling system functions through STAT3 and STAT1. Involved in the regulation of Th1- type immune responses.
Gene Information
| Human | |
|---|---|
| Gene Name: | IL27RA |
| Uniprot: | Q6UWB1 |
| Entrez: | 9466 |
Family
| Belongs to: |
|---|
| type I cytokine receptor family |
Alternative Names
class I cytokine receptor; CRL1IL-27R; Cytokine receptor-like 1; IL-27 R alpha; IL27R alpha; IL27R; IL27RA; IL-27Ra; IL-27R-alpha; interleukin 27 receptor, alpha; interleukin-27 receptor subunit alpha; TCCR; TCCRIL-27 receptor subunit alpha; T-cell cytokine receptor type 1; Type I T-cell cytokine receptor; WSX-1; WSX1IL-27R subunit alpha; zcytor1
Molecular Weight
Mass (kDA):
69.474 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19p13.12 |
| Sequence: | 19; NC_000019.10 (14031762..14053218) |
Tissue Specificity
Highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes. Weakly expressed in other tissues examined including heart, brain, fetal and adult lung, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine, kidney and colon. In the lymphoid system, higher level expression in CD4+ T-cell subsets than in CD8+ T-cell subsets. Also weaker expression in CD19+ B- cells and monocytes.
Subcellular Localizations
Membrane; Single-pass type I membrane protein.
Diseases
- Inflammation
- Autoimmune Reaction
- Neoplasms
- Malignant Neoplasms
- Autoimmune Diseases
- Lupus Erythematosus, Systemic
- Melanoma
- Glomerulonephritis
- Tissue Adhesions
- Chronic Inflammation
- Leishmaniasis, Cutaneous
- Decreased Immunologic Activity [pe]
Pathways
- Cytokine Production
- Immune Response
- Pathogenesis
- Cell Proliferation
- Cell Differentiation
- Secretion
- Cell Activation
- T Cell Proliferation
- Adaptive Immune Response
- Cell Development
- T Cell Activation
- Inflammatory Response
- Cell Cycle
PTMs
Research Areas
- Apoptosis
- Cytokine Research
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IL27RA
bosterbio.com/bosterbio-gene-info-cards/IL27RA
References
PMID: 9600072 by Sprecher C.A., et al. Cloning and characterization of a novel class I cytokine receptor.
PMID: 11057672 by Chen Q., et al. Development of Th1-type immune responses requires the type I cytokine receptor TCCR.