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Product Info Summary
| SKU: | A07616 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-Synaptopodin-2 SYNPO2 Antibody
SKU/Catalog Number
A07616
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Synaptopodin-2 SYNPO2 Antibody (Catalog # A07616). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.
Storage & Handling
SYNPO2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Synaptopodin-2 SYNPO2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A07616)
Host
Rabbit
Contents
SYNPO2 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
SYNPO2 antibody was raised against a 20 amino acid synthetic peptide near the amino terminus of human SYNPO2. The immunogen is located within amino acids 320 - 370 of SYNPO2.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
GDF1 antibody is predicted to not cross-react with any other members of the growth differentiation factor family.
Reactive Species
A07616 is reactive to SYNPO2 in Human, Mouse
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
117514 MW
Background of Synpo2
SYNPO2 was initially identified as myopodin, a member of the synaptopodin family that contains one PPXY motif and multiple PXXP motifs. It colocalizes with alpha-actinin and is found at the Z-disc and during stress conditions will translocate to the nucleus, suggesting that it is part of signaling pathways in addition to its function as a structural protein. SYNPO2 has been shown to bind to calmodulin, alpha-actinin, and smooth muscle myosin and will stimulate actin polymerization in a calmodulin dependent manner, consistent with its proposed role in organizing the cytoskeleton. While deletion of SYNPO2 has been reported to be highly correlated with the invasiveness of prostate cancers, other reports suggest that down-regulation of SYNPO2 reduces the invasiveness and motility of prostate cancer cells.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A07616 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
SYNPO2 antibody can be used for detection of SYNPO2 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of SYNPO2 in human skeletal muscle tissue lysate with SYNPO2 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
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Immunohistochemistry of SYNPO2 in mouse skeletal muscle tissue with SYNPO2 antibody at 5 μg/mL.
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Immunofluorescence of SYNPO2 in mouse skeletal muscle tissue with SYNPO2 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For SYNPO2 (Source: Uniprot.org, NCBI)
Gene Name
SYNPO2
Full Name
Synaptopodin-2
Weight
117514 MW
Superfamily
synaptopodin family
Alternative Names
Synaptopodin-2, Genethonin-2
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on SYNPO2, check out the SYNPO2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for SYNPO2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Synaptopodin-2 SYNPO2 Antibody (A07616)
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