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Product Info Summary
| SKU: | A06231 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, WB |
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Product info
Product Name
Anti-SPG15 ZFYVE26 Antibody
SKU/Catalog Number
A06231
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-SPG15 ZFYVE26 Antibody (Catalog # A06231). Tested in ELISA, WB, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
SPG15 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-SPG15 ZFYVE26 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A06231)
Host
Rabbit
Contents
SPG15 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
SPG15 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human SPG15. The immunogen is located within amino acids 1710 - 1760 of SPG15.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Multiple isoforms of SPG15 are known to exist.
Reactive Species
A06231 is reactive to ZFYVE26 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
284576 MW
Background of ZFYVE26
Hereditary spastic paraplegias (HSPs) are genetically and phenotypically heterogeneous disorders. Spastic paraplegia with thinning of the corpus callosum (ARHSP-TCC) is a relatively frequent form of complicated hereditary spastic paraplegia in which mental retardation and muscle stiffness at onset are followed by slowly progressive paraparesis and cognitive deterioration. SPG15 is the second gene known to be responsible for ARHSP-TCC in the Italian population. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15. SPG15 encodes a protein containing a FYVE zinc finger binding domain which is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. SPG15 mRNA is widely distributed in human tissues, as well as in rat embryos, suggesting a possible role for this protein during embryonic development. SPG15 co-localizes partially with endoplasmic reticulum and endosome markers, suggesting a role in intracellular trafficking.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A06231 is guaranteed for ELISA, IF, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
SPG15 antibody can be used for detection of SPG15 by Western blot at 1 - 2 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of SPG15 in K562 cell lysate with SPG15 antibody at (A) 1 and (B) 2 μg/mL.
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Immunofluorescence of SPG15 in Mouse Heart tissue with SPG15 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For ZFYVE26 (Source: Uniprot.org, NCBI)
Gene Name
ZFYVE26
Full Name
Zinc finger FYVE domain-containing protein 26
Weight
284576 MW
Alternative Names
SPG15, FYVE-CENT, KIAA0321, Zinc finger FYVE domain-containing protein 26, FYVE domain-containing centrosomal protein ZFYVE26 FYVE-CENT, SPG15 zinc finger FYVE-type containing 26 zinc finger FYVE domain-containing protein 26|FYVE domain-containing centrosomal protein|spastizin|zinc finger, FYVE domain containing 26
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on ZFYVE26, check out the ZFYVE26 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for ZFYVE26: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-SPG15 ZFYVE26 Antibody (A06231)
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