Product Info Summary
SKU: | M01887 |
---|---|
Size: | 100ul |
Reactive Species: | Human |
Host: | Mouse |
Application: | ELISA, IF, IHC, WB |
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Product info
Product Name
Anti-SorLA SORL1 Monoclonal Antibody
SKU/Catalog Number
M01887
Size
100ul
Form
Liquid
Description
Boster Bio Anti-SorLA SORL1 Monoclonal Antibody catalog # M01887. Tested in ELISA, IF, IHC, WB applications. This antibody reacts with Human.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-SorLA SORL1 Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M01887)
Host
Mouse
Contents
Ascitic fluid containing 0.03% sodium azide.
Clonality
Monoclonal
Clone Number
3B6B11
Isotype
IgG
Immunogen
Purified recombinant fragment of human SorLA expressed in E. Coli.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
M01887 is reactive to SORL1 in Human
Applications
M01887 is guaranteed for ELISA, IF, IHC, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
248426 MW
Background of SorLA
Indoleamine 2, 3-dioxygenase1 (IDO1) is a 41-42 kD intracellular enzyme that catabolizes tryptophan into kynurenine. IDO1 modulates levels of the amino acid tryptophan, which is vital for cell growth, but is also involved in the suppression of the immune response. IDO1 effects on immune suppression are due to decreased tryptophan availability and the generation of tryptophan metabolites, resulting in negative effects on T lymphocytes, including proliferation, function and survival. IDO1 may be involved in the suppression of the immune response to tumors, and blocking the IDO1 pathway may be a potential target for immuno and cancer therapy. IDO1 is expressed in a wide variety of tissues and can be upregulated by interferon gamma and other inflammatory cytokines.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB 1:500-1:2000
IHC 1:200-1:1000
IF 1:200-1:1000
ELISA 1:10000
Validation Images & Assay Conditions
Click image to see more details
Figure 3. Immunofluorescent staining data of SORL1 using Anti-SorLA SORL1 Monoclonal Antibody (M01887).
Confocal Immunofluorescence (IF) analysis of PANC-1 cells using SorLA Monoclonal Antibody (green). Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin. Blue: DRAQ5 fluorescent DNA dye.Click image to see more details
Figure 2. Immunohistochemistry validation of SORL1 using Anti-SorLA SORL1 Monoclonal Antibody (M01887).
Immunohistochemistry (IHC) analysis of paraffin-embedded human cerebrum tissues with DAB staining using SorLA Monoclonal Antibody.For more protocol information of IHC
Click image to see more details
Figure 1. Western blotting validation for Anti-SorLA SORL1 Monoclonal Antibody M01887
Western Blot (WB) analysis using SorLA Monoclonal Antibody against truncated SorLA recombinant protein.Electrophoresis was performed on a SDS-PAGE gel. To determine SDS-PAGE gel concentration
Protein Target Info & Infographic
Gene/Protein Information For SORL1 (Source: Uniprot.org, NCBI)
Gene Name
SORL1
Full Name
Sortilin-related receptor
Weight
248426 MW
Superfamily
VPS10-related sortilin family
Alternative Names
C11orf32; chromosome 11 open reading frame 32; FLJ21930; FLJ39258; gp250; Low-density lipoprotein receptor relative with 11 ligand-binding repeats; LR11; LR11LDLR relative with 11 ligand-binding repeats; LRP9; mosaic protein LR11; SORL1; SorLA; SorLA-1SORLA; sortilin-related receptor; sortilin-related receptor, L(DLR class) A repeats containing; sortilin-related receptor, L(DLR class) A repeats-containing; Sorting protein-related receptor containing LDLR class A repeats SORL1 C11orf32, LR11, LRP9, SORLA, SorLA-1, gp250 sortilin related receptor 1 sortilin-related receptor|LDLR relative with 11 ligand-binding repeats|low-density lipoprotein receptor relative with 11 ligand-binding repeats|mosaic protein LR11|sortilin-related receptor, L(DLR class) A repeats containing|sorting protein-related receptor containing LDLR class A repeats
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on SORL1, check out the SORL1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for SORL1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-SorLA SORL1 Monoclonal Antibody (M01887)
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