This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
Sortilin-related receptor Antibodies
AND SORL1 ELISA kits, Sortilin-related receptor Proteins
Many biological assays use antibodies to detect Sortilin-related receptor, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Sortilin-related receptor in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Sortilin-related receptor antibodies...
Previous: CBLIF
Next: SOS1
SORL1 Infographic by Boster Bio
All SORL1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IHC, WB
$523
Cat # M01887-1
100 µl
Cat # M01887-1
100 µl
SORL1 Overview
Facts about Sortilin-related receptor.
Sortilin-related receptor (SORL1)
Likely to be a multifunctional endocytic receptor, which might be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the significant cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis.
Binds the receptor- associated protein (RAP). Could play a role in cell-cell interaction.
Gene Information
| Human | |
|---|---|
| Gene Name: | SORL1 |
| Uniprot: | Q92673 |
| Entrez: | 6653 |
Family
| Belongs to: |
|---|
| VPS10-related sortilin family |
Alternative Names
C11orf32; chromosome 11 open reading frame 32; FLJ21930; FLJ39258; gp250; Low-density lipoprotein receptor relative with 11 ligand-binding repeats; LR11; LR11LDLR relative with 11 ligand-binding repeats; LRP9; mosaic protein LR11; SORL1; SorLA; SorLA-1SORLA; sortilin-related receptor; sortilin-related receptor, L(DLR class) A repeats containing; sortilin-related receptor, L(DLR class) A repeats-containing; Sorting protein-related receptor containing LDLR class A repeats
Molecular Weight
Mass (kDA):
248.426 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q24.1 |
| Sequence: | 11; NC_000011.10 (121452314..121633763) |
Tissue Specificity
Expressed mainly in brain, where it is most abundant in the cerebellum, cerebral cortex and the occipital pole; low expression in the putamen and the thalamus. Expression is significantly reduced in the frontal cortex of patients suffering from Alzheimer disease. According to PubMed:9157966, found in spinal cord, testis, liver, kidney and pancreas with detectable levels in placenta, lung and heart. According to PubMed:8940146, expressed in the prostate, ovary, thyroid and spleen, but not found in kidney, liver, lung, skeletal muscle, bone marrow and adrenals.
Subcellular Localizations
Golgi apparatus membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass type I membrane protein. Recycling endosome membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome, multivesicular body membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type I mem
Diseases
- Alzheimer's Disease
- Dementia
- Neurodegenerative Disorders
- Dental Plaque
- Atherosclerosis
- Nervousness
- Impaired Cognition
- Nerve Degeneration
- Tissue Adhesions
- Senile Plaques
- Plaque, Amyloid
- Mild Cognitive Disorder
- Hyperplasia
Interacting Proteins
- APP
- GGA1
- HSPA12A
Pathways
- Pathogenesis
- Transport
- Localization
- Intracellular Transport
- Cell Proliferation
- Endocytosis
- Secretion
- Aging
- Protein Processing
- Neurogenesis
- Inflammatory Response
- Cognition
- Mitosis
PTMs
- Cleavage
- Phosphorylation
- Ribosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SORL1
bosterbio.com/bosterbio-gene-info-cards/SORL1
References
PMID: 9157966 by Morwald S., et al. A novel mosaic protein containing LDL receptor elements is highly conserved in humans and chickens.
PMID: 8940146 by Jacobsen L., et al. Molecular characterization of a novel human hybrid-type receptor that binds the alpha2-macroglobulin receptor-associated protein.