Anti-Solute carrier family 22 member 5/SLC22A5 Antibody

Product Name

Anti-Solute carrier family 22 member 5/SLC22A5 Antibody

View all OCTN2/SLC22A5 Antibodies

SKU/Catalog Number

PA2174

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-Solute carrier family 22 member 5/SLC22A5 Antibody catalog # PA2174. Tested in WB applications. This antibody reacts with Mouse, Rat.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Solute carrier family 22 member 5/SLC22A5 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA2174)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of mouse Solute carrier family 22 member 5, different from the related rat sequence by two amino acids.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PA2174 is reactive to SLC22A5 in Mouse, Rat

Applications

PA2174 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

200 kDa

Calculated molecular weight

62780 MW

Background of OCTN2/SLC22A5

Solute carrier family 22 (organic cation/carnitine transporter), member 5, also called SLC22A5 or OCTN2 is a membrane transport protein associated with primary carnitine deficiency. This gene is mapped to 5q31.1. Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is a plasma integral membrane protein which functions both as an organic cation transporter and as a sodium-dependent high affinity carnitine transporter. The encoded protein is involved in the active cellular uptake of carnitine. Mutations in this gene are the cause of systemic primary carnitine deficiency (CDSP), an autosomal recessive disorder manifested early in life by hypoketotic hypoglycemia and acute metabolic decompensation, and later in life by skeletal myopathy or cardiomyopathy.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blot, 0.1-0.5μg/ml, Mouse, Rat

Validation Images & Assay Conditions

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Anti-Solute carrier family 22 member 5 antibody, PA2174, Western blotting
Lane 1: Rat Kidney Tissue Lysate
Lane 2: Rat Skeletal Muscles Tissue Lysate
Lane 3: Mouse Liver Tissue Lysate
Lane 4: HEPA Cell Lysate
Lane 5: NIH3T3 Cell Lysate

Gene/Protein Information For SLC22A5 (Source: Uniprot.org, NCBI)

Alternative Names

CDSP; FLJ46769; High-affinity sodium-dependent carnitine cotransporter; OCTN2; OCTN2high-affinity sodium dependent carnitine cotransporter; OCTN2VT; organic cation transporter 2; organic cation transporter 5; Organic cation/carnitine transporter 2; SCD; SLC22A5; solute carrier family 22 (organic cation transporter), member 5; solute carrier family 22 (organic cation/carnitine transporter), member 5; solute carrier family 22 member 5 SLC22A5 CDSP, OCTN2 solute carrier family 22 member 5 solute carrier family 22 member 5|high-affinity sodium dependent carnitine cotransporter|organic cation/carnitine transporter 2

For more info on SLC22A5, check out the SLC22A5 Infographic

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In this infographic, you will see the following information for SLC22A5: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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