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Facts about Extracellular superoxide dismutase [Cu-Zn].
Human | |
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Gene Name: | SOD3 |
Uniprot: | P08294 |
Entrez: | 6649 |
Belongs to: |
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Cu-Zn superoxide dismutase family |
ECSOD; EC-SOD; EC-SODEC 1.15.1.1; extracellular superoxide dismutase [Cu-Zn]; MGC20077; SOD3; superoxide dismutase 3, extracellular
Mass (kDA):
25.851 kDA
Human | |
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Location: | 4p15.2 |
Sequence: | 4; NC_000004.12 (24795478..24800845) |
Expressed in blood vessels, heart, lung, kidney and placenta. Major SOD isoenzyme in extracellular fluids such as plasma, lymph and synovial fluid.
Secreted, extracellular space. 99% of EC-SOD is anchored to heparan sulfate proteoglycans in the tissue interstitium, and 1% is located in the vasculature in equilibrium between the plasma and the endothelium.
PMID: 3476950 by Hjalmarsson K., et al. Isolation and sequence of complementary DNA encoding human extracellular superoxide dismutase.
PMID: 7959763 by Folz R.J., et al. Extracellular superoxide dismutase (SOD3): tissue-specific expression, genomic characterization, and computer-assisted sequence analysis of the human EC SOD gene.
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