Anti-sMtCK CKMT2 Monoclonal Antibody

Product Name

Anti-sMtCK CKMT2 Monoclonal Antibody

View all CKMT2 Antibodies

SKU/Catalog Number

M11457-1

Size

100ul

Form

Liquid

Description

Boster Bio Anti-sMtCK CKMT2 Monoclonal Antibody catalog # M11457-1. Tested in WB applications. This antibody reacts with Canine, Human, Mouse, Rabbit, Rat, Swine.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-sMtCK CKMT2 Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M11457-1)

Host

Mouse

Contents

Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.

Clonality

Monoclonal

Clone Number

2C1

Isotype

IgG

Immunogen

Purified recombinant human sMtCK protein fragments expressed in E.coli.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

M11457-1 is reactive to CKMT2 in Canine, Human, Mouse, Rabbit, Rat, Swine

Applications

M11457-1 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

47504 MW

Background of CKMT2

Epithelial splicing regulatory protein 2 (Esrp-2) is an mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. It specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2, and also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Esrp-2 acts by directly binding specific sequences in mRNAs. It binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB 1:1000-1:2000

Validation Images & Assay Conditions

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Figure 1. Western blotting validation for Anti-sMtCK CKMT2 Monoclonal Antibody M11457-1

Western Blot (WB) analysis using sMtCK Monoclonal Antibody against Rat Brain lysate.
Electrophoresis was performed on a SDS-PAGE gel. To determine SDS-PAGE gel concentration

Gene/Protein Information For CKMT2 (Source: Uniprot.org, NCBI)

Alternative Names

Basic-type mitochondrial creatine kinase; creatine kinase S-type, mitochondrial; creatine kinase, mitochondrial 2 (sarcomeric); EC 2.7.3; EC 2.7.3.2; mib-CK; Sarcomeric mitochondrial creatine kinase; SMTCK; S-MtCK CKMT2 SMTCK creatine kinase, mitochondrial 2 creatine kinase S-type, mitochondrial|S-MtCK|basic-type mitochondrial creatine kinase|creatine kinase, mitochondrial 2 (sarcomeric)|mib-CK|sarcomeric mitochondrial creatine kinase

For more info on CKMT2, check out the CKMT2 Infographic

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In this infographic, you will see the following information for CKMT2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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