Anti-Slug SNAI2 Antibody

Product Name

Anti-Slug SNAI2 Antibody

View all Slug Antibodies

SKU/Catalog Number

A01615

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-Slug SNAI2 Antibody (Catalog # A01615). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse.

Storage & Handling

Slug antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-Slug SNAI2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01615)

Host

Rabbit

Contents

Slug Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Slug antibody was raised against a 14 amino acid synthetic peptide from near the center of human Slug. The immunogen is located within amino acids 70 - 120 of Slug.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

ARSB antibody is human, mouse and rat reactive. At least two isoforms of ARSB are known to exist; this antibody only recognizes the longest isoform.

Reactive Species

A01615 is reactive to SNAI2 in Human, Mouse

Applications

A01615 is guaranteed for ELISA, WB Boster Guarantee

Observed Molecular Weight

68 kDa

Calculated molecular weight

29986 MW

Background of Slug

Slug, a member of the Snail family of C2H2-type zinc finger transcription factors, was initially identified to be involved in epithelial-mesenchymal transitions as well as the formation of the neural tube during vertebrate embryogenesis. Like Snail, Slug transcription can be induced by growth factors such as FGF, BMP, and TGF-beta. Once expressed, Slug will bind E-box regions of promoters and repress transcription of genes such as E-cadherin and Claudin-1. More recently, its expression in breast, esophogeal, and colorectal carcinomas has been correlated with poor prognosis for survival. Furthermore, Slug can protect hemapoietic progenitor cells from radiation-induced apoptosis by repressing the p53-mediated transcription of Puma, a BH3-only antagonist of the anti-apoptotic members of the Bcl-2 family. Slug antibody has no cross-reactivity to Snail protein.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Slug antibody can be used for detection of Slug by Western blot at 1 to 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

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Western blot analysis of Slug in human kidney cell lysate with Slug antibody at in (A) 1 and (B) 2 μg/mL.

Gene/Protein Information For SNAI2 (Source: Uniprot.org, NCBI)

Alternative Names

MGC10182; Neural crest transcription factor Slug; Protein snail homolog 2; slug homolog, zinc finger protein (chicken); Slug; SLUGH; SLUGH1; SLUGzinc finger protein; SNAI2; snail 2; snail homolog 2 (Drosophila); SNAIL2; WS2D; zinc finger protein SNAI2 SNAI2 SLUG, SLUGH, SLUGH1, SNAIL2, WS2D snail family transcriptional repressor 2 zinc finger protein SNAI2|neural crest transcription factor SLUG|protein snail homolog 2|slug (chicken homolog), zinc finger protein|snail family zinc finger 2|snail homolog 2

For more info on SNAI2, check out the SNAI2 Infographic

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In this infographic, you will see the following information for SNAI2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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