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Zinc finger protein SNAI2 Antibodies
AND SNAI2 ELISA kits, Zinc finger protein SNAI2 Proteins
Many biological assays use antibodies to detect Zinc finger protein SNAI2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Zinc finger protein SNAI2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Zinc finger protein SNAI2 antibodies...
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SNAI2 Infographic by Boster Bio
All SNAI2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$523
Cat # M01615-1
100 µl
Cat # M01615-1
100 µl
Human, Mouse, Rat
Flow Cytometry, IF, IHC, WB
$523
Cat # M01615-2
100 µl
Cat # M01615-2
100 µl
SNAI2 Overview
Facts about Zinc finger protein SNAI2.
Zinc finger protein SNAI2 (SNAI2)
Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1- induced transcriptional repression of the TJ protein, occludin (OCLN) and following oncogenic transformation of epithelial cells (By similarity).
Represses BRCA2 expression by binding to its E2- box-containing silencer and recruitment CTBP1 and HDAC1 in breast tissues. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription.
Gene Information
| Human | |
|---|---|
| Gene Name: | SNAI2 |
| Uniprot: | O43623 |
| Entrez: | 6591 |
Family
| Belongs to: |
|---|
| snail C2H2-type zinc-finger protein family |
Alternative Names
MGC10182; Neural crest transcription factor Slug; Protein snail homolog 2; slug homolog, zinc finger protein (chicken); Slug; SLUGH; SLUGH1; SLUGzinc finger protein; SNAI2; snail 2; snail homolog 2 (Drosophila); SNAIL2; WS2D; zinc finger protein SNAI2
Molecular Weight
Mass (kDA):
29.986 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8q11.21 |
| Sequence: | 8; NC_000008.11 (48917598..48921429, complement) |
Tissue Specificity
Expressed in most adult human tissues, including spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not detected in peripheral blood leukocyte. Expressed in the dermis and in all layers of the epidermis, with high levels of expression in the basal layers (at protein level). Expressed in osteoblasts (at protein level). Expressed in mesenchymal stem cells (at protein level). Expressed in breast tumor cells (at protein level).
Subcellular Localizations
Nucleus. Cytoplasm. Observed in discrete foci in interphase nuclei. These nuclear foci do not overlap with the nucleoli, the SP100 and the HP1 heterochromatin or the coiled body, suggesting SNAI2 is associated with active transcription or active splicing regions.
Diseases
- Malignant Neoplasms
- Neoplasms
- Cell Invasion
- Neoplasm Metastasis
- Carcinoma
- Malignant Neoplasm Of Breast
- Neoplasm Invasiveness
- Crest Syndrome
- Cell Transformation, Neoplastic
- Mammary Neoplasms
- Tissue Adhesions
- Malignant Paraganglionic Neoplasm
Interacting Proteins
- CSNK2A1
- SAT1
- TRIM23
Pathways
- Cell Migration
- Epithelial To Mesenchymal Transition
- Cell Proliferation
- Cell Cycle
- Rna Interference
- Wound Healing
- Cell Motility
- Gastrulation
- Cell Adhesion
- Cell-cell Adhesion
- Aging
- Pigmentation
- Methylation
PTMs
- Phosphorylation
- Methylation
Research Areas
- Neuronal Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SNAI2
bosterbio.com/bosterbio-gene-info-cards/SNAI2
References
PMID: 10866665 by Hemavathy K., et al. Human Slug is a repressor that localizes to sites of active transcription.
PMID: 9721220 by Cohen M.E., et al. Human SLUG gene organization, expression, and chromosome map location on 8q.
5 Publications of Boster Zinc finger protein SNAI2 Antibodies & ELISA Kits
- PubMed ID: 10.3892/ol.2021.12445, Expression of Twist, Slug and Snail in esophageal squamous cell carcinoma and th...
- PubMed ID: 10.3892/ijmm.2021.5071, Microrchidia family CW‑type zinc finger 2 promotes the proliferation, invasio...
- PubMed ID: 10.1007/s11033-016-4038-3, Phenotype transformation of immortalized NCM460 colon epithelial cell line by TG...
- PubMed ID: 10.1002/jcp.26195, Bone morphogenetic protein‐7 inhibits endothelial‐mesenchymal transition in ...
- PubMed ID: 27065079, TALENs-directed?knockout?of the?full-length?transcription?factor?Nrf1? that?repr...
*More publications can be found for each product on its corresponding product page