Anti-Schlafen family member 12 SLFN12 Antibody

Product Name

Anti-Schlafen family member 12 SLFN12 Antibody

View all SLFN12 Antibodies

SKU/Catalog Number

A16669

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-Schlafen family member 12 SLFN12 Antibody (Catalog # A16669). Tested in ELISA, WB applications. This antibody reacts with Human.

Storage & Handling

SLFN12 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-Schlafen family member 12 SLFN12 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A16669)

Host

Rabbit

Contents

SLFN12 Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

SLFN12 antibody was raised against a 12 amino acid synthetic peptide from near the carboxy terminus human SLFN12. The immunogen is located within the last 50 amino acids of SLFN12.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

ZNF821 antibody is human and mouse reactive. At least three isoforms of ZNF821 are known to exist; this antibody will detect the two largest isoforms.

Reactive Species

A16669 is reactive to SLFN12 in Human

Applications

A16669 is guaranteed for ELISA, WB Boster Guarantee

Observed Molecular Weight

68 kDa

Calculated molecular weight

66972 MW

Background of SLFN12

Despite being first described several years ago, the roles of the Schlafen (SLFN) family of proteins remain largely unknown. The SLFN genes are preferentially expressed in lymphoid tissues and differentially regulated during thymocyte maturation. It is thought that many play roles in cell growth, hemopoietic cell differentiation, and T cell development and maturation. Most members contain at least one divergent AAA domain (AAA_4) that may play a role in ATP binding. Although also known as SLFN3, a Schlafen family member that may be a marker of T cell activation, human SLFN12 has relatively low homology to SLFN3 in other species. Loss of the SLFN12 gene due to deletion is associated with Kabuki syndrome, a multiple congenital anomaly syndrome, suggesting SLFN may play a role in this genetic condition.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

SLFN12 antibody can be used for detection of SLFN12 by Western blot at 1 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

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Western blot analysis of SLFN12 in SK-N-SH cell lysate with SLFN12 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.

Gene/Protein Information For SLFN12 (Source: Uniprot.org, NCBI)

Alternative Names

schlafen family member 12 SLFN12 SLFN3 schlafen family member 12 schlafen family member 12

For more info on SLFN12, check out the SLFN12 Infographic

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In this infographic, you will see the following information for SLFN12: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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